Jet lag

Melatonin

Melatonin may help reduce jet-lag symptoms in some travelers.

moderate evidence

Direction: decrease

Magnitude: unknown

Human evidence reviewed

Study context

Population: Adults crossing time zones

Studied dose: Varies or not established

Duration: Varies across reviewed studies

Last reviewed: 2026-09-16

Limitations & caveats

  • Timing is important.

Sources

Melatonin for the prevention and treatment of jet lagSystematic review · Herxheimer and Petrie · supportsRead ›Melatonin: What You Need To KnowExpert or government fact sheet · NIH NCCIH · supportsOpen ↗

Source type and claim strength are separate. A fact sheet summarizes underlying research; its link is not an individual clinical trial.