Increased left ventricular twist, untwisting rates, and suction maintain global diastolic function during passive heat stress in humans
Nelson MD, Haykowsky MJ, Petersen SR, DeLorey DS, Cheng-Baron J, Thompson RB
American journal of physiology. Heart and circulatory physiology · 41 citations
How it was studied
- Design
- Controlled clinical trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- Canadian Institutes of Health Research
Based on 1 listed funder(s).
Publication
- Published
- 2010-01-09 · Am J Physiol Heart Circ Physiol · vol. 298 · issue 3 · pp. H930–H937
- Publisher
- American Physical Society
- Cited
- 56 citations · more than 94% of similar papers · 3.8× the field average
- Impact
- Top 10% most cited in its field
- References
- 47 works
- Access
- Paywalled
- Research areas
- Cardiovascular Function and Risk Factors · Cardiovascular Effects of Exercise · Cardiac Imaging and Diagnostics
- Keywords
- Cardiology, Internal medicine, Ejection fraction, Diastole, Stroke volume, Medicine, Preload, Fractional shortening, Twist, Blood pressure, Hemodynamics, Heart failure, Geometry
- MeSH
- heart ventricles, humans, magnetic resonance imaging, blood flow velocity, stroke volume, body temperature, diastole, adult, male, hot temperature
6 authors
From CA, US
- Michael Douglas NelsonUniversity of Alberta
- Mark J. HaykowskyAmerican Physical Therapy Association
- Stewart R. Petersen
- Darren Scott DeLorey
- June Cheng‐BaronUniversity of Alberta
- Richard B. ThompsonUniversity of Alberta
Abstract
Left ventricular (LV) systolic function increases with passive heat stress (HS); however, less is known about diastolic function. Eight healthy subjects (24.0 +/- 2.0 yr of age) underwent whole body passive heating approximately 1 degrees C above baseline (BL). Cardiac magnetic resonance imaging was used to measure biventricular volumes, function, filling velocities, volumetric flow rates, and LV twist and strain at BL and after 45 min of HS. Passive heating reduced left atrial volume (-17.6 +/- 11.7 ml, P 0.05). Early LV diastolic tissue and blood velocities and strain rates were maintained with HS, whereas untwisting rate increased significantly from 166.4 +/- 46.9 to 268.7 +/- 76.8 degrees /s (P < 0.05). The major novel finding of this study was that, secondary to an increase in peak LV twist and untwisting rate, early diastolic blood and tissue velocities and strain rates are maintained despite a reduction in filling pressure.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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