Olive oil phenols modulate the expression of metalloproteinase 9 in THP-1 cells by acting on nuclear factor-kappaB signaling
Dell'Agli M, Fagnani R, Galli GV, Maschi O, Gilardi F, Bellosta S, Crestani M, Bosisio E, De Fabiani E, Caruso D
Journal of agricultural and food chemistry · 53 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- In vitro/mechanistic study (classified by our AI screen)
- Studied in
- Cells or lab samples
- Main outcome
- Mechanisms only
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2010-01-26 · J Agric Food Chem · vol. 58 · issue 4 · pp. 2246–2252
- Publisher
- American Chemical Society
- Cited
- 71 citations · more than 98% of similar papers · 7.6× the field average
- Impact
- Top 10% most cited in its field
- References
- 38 works
- Access
- Paywalled
- Research areas
- Cholesterol and Lipid Metabolism · Atherosclerosis and Cardiovascular Diseases · Protease and Inhibitor Mechanisms
- Keywords
- Oleuropein, THP1 cell line, Chemistry, Phenols, Monocyte, Tumor necrosis factor alpha, Inflammation, Cell culture, Biochemistry, Secretion, Stimulation, Aglycone, Olive oil, Pharmacology, Biology, Food science, Endocrinology, Immunology, Stereochemistry
- MeSH
- cell line, tumor, humans, leukemia, myeloid, phenols, plant oils, tumor necrosis factor-alpha, nf-kappa b, dna primers, reverse transcriptase polymerase chain reaction, signal transduction, transcription, genetic, gene expression regulation, enzymologic, gene expression regulation, neoplastic, matrix metalloproteinase 9, promoter regions, genetic, olive oil
10 authors
From IT
- Mario Dell’Agli · correspondingUniversity of Milan
- Rossana Fagnani
- Germana V. Galli
- Omar Maschi
- Federica Gilardi
- Stefano Bellosta
Abstract
In vivo studies suggest that the phenolic component contributes to the anti-inflammatory and antiatherosclerotic actions of olive oil; however, the effects in circulating cells are not fully characterized. Monocytes play a key role in inflammation-based diseases by expressing several molecules, including metalloproteinases (MMPs). In the present study, we investigated the effects of olive oil phenolic extract and individual compounds on MMP-9 in THP-1 cells, a human monocyte-like cell line. Olive oil extract prevented the stimulation of MMP-9 expression and secretion in tumor necrosis factor alpha-treated THP-1 cells. Oleuropein aglycone, a typical olive oil phenol, was active at concentrations found in the extract, although other compounds probably contribute to the biological activity. We also found that the effect of the extract and individual compounds on MMP-9 is due to impaired nuclear factor-kappaB signaling. Our findings provide further evidence on the mechanisms by which olive oil reduces the inflammatory burden associated with disorders, such as atherosclerosis.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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