In vivo nutrigenomic effects of virgin olive oil polyphenols within the frame of the Mediterranean diet: a randomized controlled trial
Konstantinidou V, Covas MI, Muñoz-Aguayo D, Khymenets O, de la Torre R, Saez G, Tormos Mdel C, Toledo E, Marti A, Ruiz-Gutiérrez V, Ruiz Mendez MV, Fito M
FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 186 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Mechanisms only
- Intake measured by
- Not stated
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2010-02-23 · FASEB J · vol. 24 · issue 7 · pp. 2546–2557
- Publisher
- Wiley
- Cited
- 273 citations · more than 100% of similar papers · 22.1× the field average
- Impact
- Top 10% most cited in its field
- References
- 63 works
- Access
- Paywalled
- Research areas
- Nutritional Studies and Diet · Fatty Acid Research and Health · Cholesterol and Lipid Metabolism
- Keywords
- Polyphenol, Food science, Oxidative stress, Mediterranean diet, Chemistry, Olive oil, Medicine, Internal medicine, Biochemistry, Antioxidant
- MeSH
- humans, cardiovascular diseases, inflammation, phenols, flavonoids, plant oils, gene expression regulation, down-regulation, oxidation-reduction, diet, mediterranean, adult, middle aged, atherosclerosis, nutrigenomics, young adult, polyphenols, olive oil
12 authors
From ES
- Valentini KonstantinidouCentro de Investigación Biomédica en Red; Hospital Del Mar; Municipal Institute for Medical Research
- María‐Isabel Covas · correspondingCentro de Investigación Biomédica en Red; Hospital Del Mar; Municipal Institute for Medical Research
- Daniel Muñoz‐AguayoCentro de Investigación Biomédica en Red; Hospital Del Mar; Municipal Institute for Medical Research
- Olha KhymenetsCentro de Investigación Biomédica en Red; Municipal Institute for Medical Research; Hospital del Mar Research Institute
- Rafael de la TorreCentro de Investigación Biomédica en Red; Municipal Institute for Medical Research; Hospital del Mar Research Institute
- Guillermo T. SáezUniversitat de València
Abstract
The aim of the study was to assess whether benefits associated with the traditional Mediterranean diet (TMD) and virgin olive oil (VOO) consumption could be mediated through changes in the expression of atherosclerosis-related genes. A randomized, parallel, controlled clinical trial in healthy volunteers (n=90) aged 20 to 50 yr was performed. Three-month intervention groups were as follows: 1) TMD with VOO (TMD+VOO), 2) TMD with washed virgin olive oil (TMD+WOO), and 3) control with participants' habitual diet. WOO was similar to VOO, but with a lower polyphenol content (55 vs. 328 mg/kg, respectively). TMD consumption decreased plasma oxidative and inflammatory status and the gene expression related with both inflammation [INF-gamma (INFgamma), Rho GTPase-activating protein15 (ARHGAP15), and interleukin-7 receptor (IL7R)] and oxidative stress [adrenergic beta(2)-receptor (ADRB2) and polymerase (DNA-directed) kappa (POLK)] in peripheral blood mononuclear cells. All effects, with the exception of the decrease in POLK expression, were particularly observed when VOO, rich in polyphenols, was present in the TMD dietary pattern. Our results indicate a significant role of olive oil polyphenols in the down-regulation of proatherogenic genes in the context of a TMD. In addition, the benefits associated with a TMD and olive oil polyphenol consumption on cardiovascular risk can be mediated through nutrigenomic effects.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.