Effects of a 1-year dietary intervention with n-3 polyunsaturated fatty acid-enriched olive oil on non-alcoholic fatty liver disease patients: a preliminary study
Sofi F, Giangrandi I, Cesari F, Corsani I, Abbate R, Gensini GF, Casini A
International journal of food sciences and nutrition · 91 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2010-05-13 · Int J Food Sci Nutr · vol. 61 · issue 8 · pp. 792–802
- Publisher
- Taylor & Francis
- Cited
- 122 citations · more than 95% of similar papers · 4.8× the field average
- Impact
- Top 10% most cited in its field
- References
- 17 works
- Access
- Paywalled
- Research areas
- Liver Disease Diagnosis and Treatment · Fatty Acid Research and Health · Edible Oils Quality and Analysis
- Keywords
- Polyunsaturated fatty acid, Medicine, Adiponectin, Fatty liver, Internal medicine, Fatty acid, Gastroenterology, Food science, Disease, Biology, Biochemistry, Obesity, Insulin resistance
- MeSH
- liver, humans, fatty liver, enzymes, dietary fats, fatty acids, omega-3, triglycerides, plant oils, pilot projects, food, fortified, adult, aged, middle aged, female, male, adiponectin, olive oil
7 authors
From IT
- Francesco Sofi · correspondingAzienda Ospedaliero-Universitaria Careggi; University of Florence
- Ilaria GiangrandiAzienda Ospedaliero-Universitaria Careggi; University of Florence
- Francesca CesariUniversity of Florence
- Ilaria CorsaniAzienda Ospedaliero-Universitaria Careggi; University of Florence
- Rosanna AbbateUniversity of Florence
- Gian Franco GensiniDon Carlo Gnocchi Foundation
Abstract
Background and aims
Non-alcoholic fatty liver disease (NAFLD) is a worldwide diffuse condition due to alimentary, environment and genetic factors. The aim of our preliminary study was to evaluate the effectiveness of long-term consumption of food enriched with n-3 polyunsaturated fatty acids (PUFA) in patients with NAFLD.
Methods
Eleven patients were enrolled; six (four males, two females) were planned for oral administration of 6.5 ml olive oil enriched with n-3 PUFA for 12 months, while five (four males, one female) were used as controls.
Results
Consumption of olive oil enriched with n-3 PUFA demonstrated a significant improvement of liver echo-texture and of the Doppler Perfusion Index after 12 months (after: 0.19 ± 0.02 vs. pre: 0.15 ± 0.03; P < 0.05), whereas no significant changes were seen at the end of follow-up in controls. Moreover, patients who consumed the olive oil enriched with n-3 PUFA showed a significant amelioration of liver enzymes, and of triglycerides (post: 132.8 ± 63.7 vs. pre: 164.5 ± 85.5 mg/dl; P = 0.04) in a general linear model adjusted for age and gender. Interestingly, patients reported to have a significant increase of adiponectin levels (post: 1,487.9 ± 96.7 vs. pre: 1,143 ± 24.8 μg/ml; P = 0.04).
Conclusion
The results of this preliminary study showed that long-term consumption of olive oil enriched with n-3 PUFA in patients with NAFLD is able to decrease circulating liver enzymes and triglycerides, with a significant improvement of adiponectin levels.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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