Randomized clinical trial of intravenous soybean oil alone versus soybean oil plus fish oil emulsion after gastrointestinal cancer surgery
Jiang ZM, Wilmore DW, Wang XR, Wei JM, Zhang ZT, Gu ZY, Wang S, Han SM, Jiang H, Yu K
The British journal of surgery · 60 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- Government
- National Health and Family Planning Commission of the People's Republic of China
- Government
- Chinese Ministry of Health
Based on 2 listed funder(s).
Publication
- Published
- 2010-04-22 · Br J Surg · vol. 97 · issue 6 · pp. 804–809
- Publisher
- Oxford University Press
- Cited
- 80 citations · more than 95% of similar papers · 5.0× the field average
- Impact
- Top 10% most cited in its field
- References
- 21 works
- Access
- Paywalled
- Research areas
- Clinical Nutrition and Gastroenterology · Enhanced Recovery After Surgery · Fatty Acid Research and Health
- Keywords
- Medicine, Interquartile range, Fish oil, Randomized controlled trial, Parenteral nutrition, Soybean oil, Surgery, Adverse effect, Gastrointestinal cancer, Clinical trial, Incidence (geometry), Systemic inflammatory response syndrome, Gastrointestinal function, Gastroenterology, Anesthesia, Internal medicine, Cancer, Colorectal cancer, Fish <Actinopterygii>, Sepsis
- MeSH
- humans, respiratory tract infections, urinary tract infections, surgical wound infection, gastrointestinal neoplasms, colonic neoplasms, postoperative complications, body weight, soybean oil, fish oils, tumor necrosis factor-alpha, interleukin-6, emulsions, body mass index, cd4-cd8 ratio, length of stay, postoperative care, infusions, intravenous, analysis of variance, aged, middle aged, cost-benefit analysis, female, male
10 authors
From CN, US
- Zhu Jiang · correspondingChinese Academy of Medical Sciences & Peking Union Medical College
- Douglas W. WilmoreBrigham and Women's Hospital; Harvard University
- Xun WangChinese Academy of Medical Sciences & Peking Union Medical College
- Jinqi WeiBeijing Hospital
- Z T ZhangCapital Medical University; Beijing Friendship Hospital
- Zixiao Gu
Abstract
Background
Specific immunonutrients may reduce the incidence of postoperative complications and shorten recovery time. This randomized trial evaluated the clinical efficacy of a fish oil emulsion on outcome and immune function after gastrointestinal cancer surgery.
Methods
A total of 206 patients with gastrointestinal or colonic cancer were randomized to receive isocaloric and isonitrogenous intravenous infusions of either soybean oil alone (1.2 g per kg bodyweight per day; control group, 103 analysed) or soybean plus fish oil emulsion (1.0 and 0.2 g per kg per day respectively; treatment group, 100 analysed) over 20-24 h daily for 7 days after surgery.
Results
Baseline data were comparable in the two groups. There were fewer infectious complications (four versus 12 on day 8; P = 0.066), systemic inflammatory response syndrome (SIRS) was significantly less common (four versus 13; P = 0.039) and hospital stay was significantly shorter (mean(s.d.) 15(5) versus 17(8) days; P = 0.041) in the treatment group. Total postoperative medical costs were comparable in the two groups (mean(s.d.) US $ 1269(254) and 1302(324) in treatment and control groups respectively; P = 0.424). The median (interquartile range) difference in CD4/CD8 between days 1 and 8 after surgery was + 0.30 (0.06 to 0.79) in patients receiving fish oil and + 0.20 (-0.19 to 0.55) in controls (P = 0.021). No severe adverse events occurred in either group.
Conclusion
Fish oil emulsion-supplemented parenteral nutrition significantly reduced SIRS and length of hospital stay. These clinical benefits may be related to normalization of cellular immune functions and modulation of the inflammatory response.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.