Intake of cruciferous vegetables modifies bladder cancer survival
Tang L, Zirpoli GR, Guru K, Moysich KB, Zhang Y, Ambrosone CB, McCann SE
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 91 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Independent funding
- Government
- National Cancer Institute
- Government
- NCI NIH HHS
- Grants
- National Cancer Institute (R25CA114101)
Based on 2 listed funder(s).
Publication
- Published
- 2010-07-01 · Cancer Epidemiol Biomarkers Prev · vol. 19 · issue 7 · pp. 1806–1811
- Publisher
- American Association for Cancer Research
- Cited
- 124 citations · more than 94% of similar papers · 3.9× the field average
- Impact
- Top 10% most cited in its field
- References
- 26 works
- Access
- Free to read
- Research areas
- Genomics, phytochemicals, and oxidative stress · Sulfur Compounds in Biology · Phytochemicals and Antioxidant Activities
- Keywords
- Cruciferous vegetables, Medicine, Bladder cancer, Hazard ratio, Cancer, Proportional hazards model, Cancer registry, Internal medicine, Confidence interval
- MeSH
- humans, brassica, vegetables, isothiocyanates, prognosis, diet, seer program, risk factors, survival analysis, prospective studies, aged, aged, 80 and over, middle aged, united states, female, male, urinary bladder neoplasms, surveys and questionnaires
7 authors
From US
- Li Tang · correspondingRoswell Park Comprehensive Cancer Center
- Gary ZirpoliRoswell Park Comprehensive Cancer Center
- Khurshid A. GuruRoswell Park Comprehensive Cancer Center
- Kirsten B. MoysichRoswell Park Comprehensive Cancer Center
- Yuesheng ZhangRoswell Park Comprehensive Cancer Center
- Christine B. AmbrosoneRoswell Park Comprehensive Cancer Center
Abstract
Background
Intake of cruciferous vegetables, a rich source of dietary isothiocyanates, has been inversely associated with risk of bladder cancer. Due to the potent antiproliferative effects of dietary isothiocyanates on bladder cancer in in vitro and in vivo models, cruciferous vegetable intake may also play a role in survival among patients with bladder cancer.
Methods
Using information obtained from the Roswell Park Cancer Institute Tumor Registry, patient medical records, and routinely collected questionnaire data, we examined potential associations between intake of cruciferous vegetables and survival among bladder cancer patients. As cooking can substantially reduce or destroy isothiocyanates, consumption of raw versus cooked cruciferous vegetables was examined separately. Hazard ratios (HR) and 95% confidence intervals (CI) were estimated using Cox proportional hazard models.
Results
A total of 239 bladder cancer patients were included in the study. After an average of 8 years of follow-up, 179 deaths occurred, with 101 deaths attributable to bladder cancer. After adjustment for other prognostic factors, a strong and significant inverse association was observed between bladder cancer mortality and broccoli intake, in particular raw broccoli intake (> or =1 versus <1 serving per month; HR for overall death, 0.57; 95% CI, 0.39-0.83; HR for disease-specific death, 0.43; 95% CI, 0.25-0.74). There were no significant associations for total vegetables, total fruits, or other individual cruciferous vegetables.
Conclusions
Considering the strong preclinical evidence, intake of broccoli may improve bladder cancer survival.
Impact
Further prospective investigation is warranted to confirm the potential role of cruciferous vegetables in bladder cancer prognosis.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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