Canola oil inhibits breast cancer cell growth in cultures and in vivo and acts synergistically with chemotherapeutic drugs
Cho K, Mabasa L, Fowler AW, Walsh DM, Park CS
Lipids · 12 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- In vitro/mechanistic study (classified by our AI screen)
- Studied in
- People, plus animal or lab work
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2010-08-21 · Lipids · vol. 45 · issue 9 · pp. 777–784
- Publisher
- Wiley
- Cited
- 25 citations · more than 76% of similar papers · 0.9× the field average
- References
- 32 works
- Access
- Paywalled
- Research areas
- Cancer, Lipids, and Metabolism · Inflammatory mediators and NSAID effects · Tannin, Tannase and Anticancer Activities
- Keywords
- Tamoxifen, In vivo, Breast cancer, Cell growth, Cancer, Apoptosis, Cerulenin, Cancer research, Cancer cell, Carcinogenesis, Medicine, Programmed cell death, Pharmacology, Internal medicine, Endocrinology, Chemistry, Biology, Biochemistry, Lipid metabolism
- MeSH
- cell line, tumor, animals, humans, rats, rats, sprague-dawley, breast neoplasms, cerulenin, tamoxifen, fatty acids, monounsaturated, antineoplastic combined chemotherapy protocols, cell proliferation, drug synergism, female, tumor suppressor protein p53, caspase 3, rapeseed oil
5 authors
From US
- Kyongshin ChoNorth Dakota State University
- Lawrence MabasaNorth Dakota State University
- Andrea W. FowlerNorth Dakota State University
- Dana M. WalshNorth Dakota State University
- Chung S. Park · correspondingNorth Dakota State University
Abstract
Certain fatty acids in canola oil (CAN) have been associated with a reduced risk of breast cancer. This study assessed the effects of CAN on proliferation and death of human breast cancer cells in vitro and in vivo in chemically induced mammary carcinogenesis. We hypothesize that CAN reduces breast cancer cell growth by inducing cell death. In a series of in vitro experiments, human breast cancer T47D and MCF-7 cells were cultured and treated with CAN and two chemotherapeutic drugs, tamoxifen and cerulenin. Cell proliferation and caspase-3 and p53 activities were measured. Reduced cancer cell growth and increased expression of caspase-3 and p53 were seen in T47D and MCF-7 cells treated with CAN. Moreover, CAN showed synergistic cancer cell growth inhibition effects with tamoxifen and cerulenin. In a subsequent live animal experiment, 42 female Sprague-Dawley rats were randomly assigned to corn oil (CORN) or CAN diets, and mammary tumors were chemically induced by N-nitroso-N-methylurea. CAN-dieted rats had reduced tumor volumes and showed an increased survival rate as compared to CORN-dieted rats. We demonstrated that CAN has suppressive effects on cancer growth, and reduces tumor volumes. The results suggest that CAN may have inhibitory effects on breast cancer cell growth, and warrants further investigation of the synergistic effects of CAN with anti-cancer drugs.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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