Ingestion of broccoli sprouts does not improve endothelial function in humans with hypertension
Christiansen B, Bellostas Muguerza N, Petersen AM, Kveiborg B, Madsen CR, Thomas H, Ihlemann N, Sørensen JC, Køber L, Sørensen H, Torp-Pedersen C, Domínguez H
PloS one · 34 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Food provided by researchers
Who paid for it
- Funding
- Independent funding
- Nonprofit
- Hjerteforeningen
- Nonprofit
- Beckett-Fonden
Based on 2 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2010-08-27 · PLoS One · vol. 5 · issue 8 · p. e12461
- Publisher
- Public Library of Science
- Cited
- 43 citations · more than 63% of similar papers · 0.5× the field average
- References
- 31 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Genomics, phytochemicals, and oxidative stress · Phytochemicals and Antioxidant Activities · Free Radicals and Antioxidants
- Keywords
- Blood pressure, Medicine, Ingestion, Endothelium, Diabetes mellitus, Oxidative stress, Essential hypertension, Internal medicine, Endocrinology, Physiology
- MeSH
- endothelium, vascular, humans, brassica, hypertension, glucosinolates, blood pressure, blood circulation, vasodilation, eating, adult, aged, middle aged, female, male
12 authors
From DK, US
- Buris Christiansen · correspondingHerlev Hospital; Copenhagen University Hospital; The Capital Region Pharmacy
- Natalia Bellostas MuguerzaUniversity of Copenhagen
- Atheline Major PetersenOdense University Hospital
- Britt KveiborgPsychiatry Region Zealand
- Christian Rask MadsenJoslin Diabetes Center
- Hermann ThomasJoslin Diabetes Center
Abstract
Unlabelled
Ingestion of glucosinolates has previously been reported to improve endothelial function in spontaneously hypertensive rats, possibly because of an increase in NO availability in the endothelium due to an attenuation of oxidative stress; in our study we tried to see if this also would be the case in humans suffering from essential hypertension.
Methods
40 hypertensive individuals without diabetes and with normal levels of cholesterol were examined. The participants were randomized either to ingest 10 g dried broccoli sprouts, a natural donor of glucosinolates with high in vitro antioxidative potential, for a 4 week period or to continue their ordinary diet and act as controls. Blood pressure, endothelial function measured by flow mediated dilation (FMD) and blood samples were obtained from the participants every other week and the content of glucosinolates was measured before and after the study. Measurements were blinded to treatment allocation.
Results
In the interventional group overall FMD increased from 4% to 5.8% in the interventional group whereas in the control group FMD was stable (4% at baseline and 3.9% at the end of the study). The change in FMD in the interventional group was mainly due to a marked change in FMD in two participants while the other participants did not have marked changes in FMD. The observed differences were not statistically significant. Likewise significant changes in blood pressure or blood samples were not detected between or within groups. Diastolic blood pressure stayed essentially unchanged in both groups, while the systolic blood pressure showed a small non significant decrease (9 mm Hg) in the interventional group from a value of 153 mm Hg at start.
Conclusion
Daily ingestion of 10 g dried broccoli sprouts does not improve endothelial function in the presence of hypertension in humans.
Trial registration
Clinicaltrials.gov NCT00252018.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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