Cruciferous vegetable intake and lung cancer risk: a nested case-control study matched on cigarette smoking
Lam TK, Ruczinski I, Helzlsouer KJ, Shugart YY, Caulfield LE, Alberg AJ
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 38 citations
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- Government
- National Institute on Aging
- Government
- National Cancer Institute
- Government
- NIA NIH HHS
- Government
- NCI NIH HHS
- Grants
- National Institute on Aging (5U01AG018033); National Cancer Institute (P30-CA138313); National Institute on Aging (U01 AG018033); National Cancer Institute (T32CA009314); National Cancer Institute (CA105069); National Cancer Institute (R01CA105069)
Based on 4 listed funder(s).
Publication
- Published
- 2010-10-01 · Cancer Epidemiol Biomarkers Prev · vol. 19 · issue 10 · pp. 2534–2540
- Publisher
- American Association for Cancer Research
- Cited
- 55 citations · more than 89% of similar papers · 2.5× the field average
- References
- 45 works
- Access
- Free to read
- Research areas
- Genomics, phytochemicals, and oxidative stress · Antioxidant Activity and Oxidative Stress · Nutritional Studies and Diet
- Keywords
- Cruciferous vegetables, Nested case-control study, Medicine, Lung cancer, Cigarette smoking, Environmental health, Case-control study, Oncology, Cancer, Internal medicine
- MeSH
- humans, vegetables, lung neoplasms, diet, risk assessment, risk factors, case-control studies, cohort studies, prospective studies, smoking, smoking cessation, middle aged
6 authors
From US, UA
- Tram Kim LamMercy Medical Center; Johns Hopkins University; Hagerstown Community College; National Cancer Institute; National Cancer Institute; Mercy Medical Center; Division of Cancer Epidemiology and Genetics
- Ingo RuczinskiMercy Medical Center; Johns Hopkins University; Medical University of South Carolina; Hagerstown Community College; MUSC Hollings Cancer Center; National Cancer Institute; National Cancer Institute; Mercy Medical Center; Division of Cancer Epidemiology and Genetics
- Kathy J. HelzlsouerMercy Medical Center; Johns Hopkins University; Hagerstown Community College; National Cancer Institute; National Cancer Institute; Mercy Medical Center; Division of Cancer Epidemiology and Genetics
- Yin Yao ShugartMercy Medical Center; Johns Hopkins University; Medical University of South Carolina; Hagerstown Community College; MUSC Hollings Cancer Center; National Cancer Institute; National Cancer Institute; Mercy Medical Center; Division of Cancer Epidemiology and Genetics
- Laura E. CaulfieldMercy Medical Center; Johns Hopkins University; Medical University of South Carolina; Hagerstown Community College; MUSC Hollings Cancer Center; National Cancer Institute; National Cancer Institute; Mercy Medical Center; Division of Cancer Epidemiology and Genetics
- Anthony J. Alberg · correspondingMercy Medical Center; Johns Hopkins University; Hagerstown Community College; National Cancer Institute; National Cancer Institute; Mercy Medical Center; Division of Cancer Epidemiology and Genetics
Abstract
Background
Due predominantly to cigarette smoking, lung cancer is the leading cancer-related cause of death worldwide. Cruciferous vegetables may reduce lung cancer risk. The association between intake of cruciferous vegetables and lung cancer risk was investigated in the CLUE II study, a community-based cohort established in 1989.
Methods
We matched 274 incident cases of lung cancer diagnosed from 1990 to 2005 to 1,089 cancer-free controls on age, sex, and cigarette smoking. Dietary information was collected at baseline. Multivariable odds ratios (OR) and 95% confidence intervals (95% CI) were calculated using conditional logistic regression.
Results
Intake of cruciferous vegetables was inversely associated with lung cancer risk (highest-versus-lowest fourth: OR (Q4vsQ1), 0. 57; 95% CI, 0.38-0.85; P-trend = 0.01). The inverse associations held true for former smokers (OR(Q4vsQ1), 0.49; 95% CI, 0.27-0.92; P-trend = 0.05) and current smokers (OR(Q4vsQ1), 0.52; 95% CI, 0.29-0.95; P-trend = 0.02).
Conclusions
After carefully controlling for cigarette smoking, higher intake of cruciferous vegetable was associated with lower risk of lung cancer.
Impact
The observed inverse association coupled with accumulating evidence suggests that intake of cruciferous vegetables is inversely associated with lung cancer risk, and this association seems to hold true beyond the confounding effects of cigarette smoking.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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