Replacing dairy fat with rapeseed oil causes rapid improvement of hyperlipidaemia: a randomized controlled study
Iggman D, Gustafsson IB, Berglund L, Vessby B, Marckmann P, Risérus U
Journal of internal medicine · 58 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Food provided by researchers
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2011-04-05 · J Intern Med · vol. 270 · issue 4 · pp. 356–364
- Publisher
- Wiley
- Cited
- 86 citations · more than 95% of similar papers · 4.5× the field average
- Impact
- Top 10% most cited in its field
- References
- 51 works
- Access
- Free to read
- Research areas
- Fatty Acid Research and Health · Nutritional Studies and Diet · Nuts composition and effects
- Keywords
- Medicine, Rapeseed, Randomized controlled trial, Food science, Environmental health, Internal medicine
- MeSH
- humans, cholesterol, dietary fats, unsaturated, fatty acids, fatty acids, monounsaturated, lipoproteins, plant oils, analysis of variance, cross-over studies, double-blind method, dairy products, sweden, female, male, hyperlipidemias, rapeseed oil
6 authors
From SE, DK
- David Iggman · correspondingUppsala University; Center for Clinical Research Dalarna
- Inga‐Britt GustafssonÖrebro University
- Lars BerglundUppsala University
- B. VessbyUppsala University
- Peter MarckmannUniversity of Southern Denmark; Odense University Hospital
- Ulf Risérus · correspondingUppsala University
Abstract
Background
Rapeseed oil (RO), also known as canola oil, principally contains the unsaturated fatty acids 18:1n-9, 18:2n-6 and 18:3n-3 and may promote cardiometabolic health.
Objective
To investigate the effects on lipoprotein profile, factors of coagulation and insulin sensitivity of replacing a diet rich in saturated fat from dairy foods (DF diet) with a diet including RO-based fat (RO diet).
Design
During a 2×3-week randomized, controlled, cross-over trial, 20 free-living hyperlipidaemic subjects were provided with isocaloric test diets that differed in fat composition alone. Blood lipoprotein profile, coagulation and fibrinolytic factors and insulin sensitivity (euglycaemic clamp) were determined before and after the dietary intervention.
Results
All subjects completed the study, and compliance was high according to changes in serum fatty acids. The RO diet, but not the DF diet, reduced the levels of serum cholesterol (-17%), triglycerides (-20%) and low-density lipoprotein cholesterol (-17%), cholesterol/high-density lipoprotein (HDL) cholesterol ratio (-21%), apolipoprotein (apo) B/apo A-I ratio (-4%) and factor VII coagulant activity (FVIIc) (-5%) from baseline. These changes were significantly different between the diets (P=0.05 to P<0.0001), except for FVIIc (P=0.1). The RO diet, but not the DF diet, modestly increased serum lipoprotein(a) (+6%) and tended to increase the glucose disappearance rate (K-value, +33%). HDL cholesterol, insulin sensitivity, fibrinogen and tissue plasminogen activator inhibitor-1 levels did not change from baseline or differ between the two diets.
Conclusions
In a diet moderately high in total fat, replacing dairy fat with RO causes a rapid and clinically relevant improvement in serum lipoprotein profile including lowering of triglycerides in hyperlipidaemic individuals.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.