Pancreatic cancer and exposure to dietary nitrate and nitrite in the NIH-AARP Diet and Health Study
Aschebrook-Kilfoy B, Cross AJ, Stolzenberg-Solomon RZ, Schatzkin A, Hollenbeck AR, Sinha R, Ward MH
American journal of epidemiology · 38 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Independent funding
- Government
- National Institutes of Health
- Government
- Intramural NIH HHS
Based on 2 listed funder(s).
Publication
- Published
- 2011-06-17 · Am J Epidemiol · vol. 174 · issue 3 · pp. 305–315
- Publisher
- Oxford University Press
- Cited
- 53 citations · more than 95% of similar papers · 5.3× the field average
- Impact
- Top 10% most cited in its field
- References
- 54 works
- Access
- Free to read
- Research areas
- Nutritional Studies and Diet · Diet and metabolism studies · Colorectal Cancer Screening and Detection
- Keywords
- Nitrite, Nitrate, Pancreatic cancer, Confidence interval, Medicine, Hazard ratio, Cancer, Internal medicine, Food science, Physiology, Gastroenterology, Chemistry, Biology, Ecology
- MeSH
- humans, pancreatic neoplasms, nitrates, nitrites, diet, diet surveys, multivariate analysis, confidence intervals, proportional hazards models, risk factors, sex factors, meat products, aged, middle aged, united states, male, surveys and questionnaires
7 authors
From US
- Brisa Aschebrook-Kilfoy · correspondingNational Cancer Institute; Division of Cancer Epidemiology and Genetics
- Amanda Jane CrossNational Cancer Institute; Division of Cancer Epidemiology and Genetics
- Rachael Z. Stolzenberg‐SolomonNational Cancer Institute; Division of Cancer Epidemiology and Genetics
- Arthur G. SchatzkinNational Cancer Institute; Division of Cancer Epidemiology and Genetics
- A. R. HollenbeckNational Cancer Institute; Division of Cancer Epidemiology and Genetics
- Rashmi R. SinhaNational Cancer Institute; Division of Cancer Epidemiology and Genetics
Abstract
Nitrate and nitrite are precursors of N-nitroso compounds, which induce tumors of the pancreas in animals. The authors evaluated the relation of dietary nitrate and nitrite to pancreatic cancer risk in the NIH-AARP Diet and Health Study. Nitrate and nitrite intakes were assessed at baseline using a 124-item food frequency questionnaire. During approximately 10 years of follow-up between 1995 and 2006, 1,728 incident pancreatic cancer cases were identified. There was no association between total nitrate or nitrite intake and pancreatic cancer in men or women. However, men in the highest quintile of summed nitrate/nitrite intake from processed meat had a nonsignificantly elevated risk of pancreatic cancer (hazard ratio = 1.18, 95% confidence interval: 0.95, 1.47; P-trend = 0.11). The authors observed a stronger increase in risk among men for nitrate/nitrite intake from processed meat at ages 12-13 years (highest quintile vs. lowest: hazard ratio = 1.32, 95% confidence interval: 0.99, 1.76; P-trend = 0.11), though the relation did not achieve statistical significance. The authors found no associations between adult or adolescent nitrate or nitrite intake from processed meats and pancreatic cancer among women. These results provide modest evidence that processed meat sources of dietary nitrate and nitrite may be associated with pancreatic cancer among men and provide no support for the hypothesis in women.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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