Epithelial ovarian cancer and exposure to dietary nitrate and nitrite in the NIH-AARP Diet and Health Study
Aschebrook-Kilfoy B, Ward MH, Gierach GL, Schatzkin A, Hollenbeck AR, Sinha R, Cross AJ
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) · 26 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Independent funding
- Government
- U.S. Department of Agriculture
- Government
- National Institutes of Health
- Government
- Intramural NIH HHS
- Grants
- National Institutes of Health (Z01 CP010196)
Based on 3 listed funder(s).
Publication
- Published
- 2011-10-04 · Eur J Cancer Prev · vol. 21 · issue 1 · pp. 65–72
- Publisher
- Lippincott Williams & Wilkins
- Cited
- 40 citations · more than 93% of similar papers · 4.1× the field average
- Impact
- Top 10% most cited in its field
- References
- 35 works
- Access
- Open access (repository copy)
- Research areas
- Nutritional Studies and Diet · Phytoestrogen effects and research · Diet, Metabolism, and Disease
- Keywords
- Nitrite, Nitrate, Medicine, Dietary Nitrate, Ovarian cancer, Cancer, Epithelial ovarian cancer, Physiology, Environmental health, Internal medicine, Gynecology, Oncology, Biology, Ecology
- MeSH
- humans, adenocarcinoma, clear cell, adenocarcinoma, mucinous, ovarian neoplasms, endometrial neoplasms, nitrates, nitrites, diet, diet surveys, incidence, risk factors, prospective studies, national institutes of health (u.s.), adult, aged, middle aged, united states, female
7 authors
From US
- Briseis Aschebrook‐Kilfoy · correspondingNational Institutes of Health
- Mary H. Ward
- Gretchen L. Gierach
- Arthur G. SchatzkinNational Institutes of Health; National Cancer Institute
- Albert R. HollenbeckAARP
- Rashmi R. SinhaNational Institutes of Health; National Cancer Institute
Abstract
Ovarian cancer is a leading cause of cancer death among women in the United States and it has the highest mortality rate of all gynecologic cancers. Internationally, there is a five-fold variation in incidence and mortality of ovarian cancer, which suggests a role for environmental factors, including diet. Nitrate and nitrite are found in various food items and they are precursors of N-nitroso compounds, which are known carcinogens in animal models. We evaluated dietary nitrate and nitrite intake and epithelial ovarian cancer in the National Institutes of Health (NIH)-AARP Diet and Health Study, including 151 316 women aged 50-71 years at the time of the baseline questionnaire in 1995-1996. The nitrate and nitrite intake was assessed using a 124-item validated food frequency questionnaire. Through 31 December 2006, 709 incident epithelial ovarian cancer cases with complete dietary information were identified. Using Cox proportional hazards regression to estimate hazard ratios and 95% confidence intervals (CIs), women in the highest intake quintile of dietary nitrate had a 31% increased risk (95% CI: 1.01-1.68) of epithelial ovarian cancer, compared with those in the lowest intake quintile. Although there was no association for total dietary nitrite, those in the highest intake category of animal sources of nitrite had a 34% increased risk (95% CI: 1.05-1.69) of ovarian cancer. There were no clear differences in risk by histologic subtype of ovarian cancer. Our findings suggest that a role of dietary nitrate and nitrite in ovarian cancer risk should be followed in other large cohort studies.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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