Modulation of the metabolism of airborne pollutants by glucoraphanin-rich and sulforaphane-rich broccoli sprout beverages in Qidong, China
Kensler TW, Ng D, Carmella SG, Chen M, Jacobson LP, Muñoz A, Egner PA, Chen JG, Qian GS, Chen TY, Fahey JW, Talalay P, Groopman JD, Yuan JM, Hecht SS
Carcinogenesis · 102 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Mechanisms only
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- Government
- National Cancer Institute
- Government
- National Institute of Environmental Health Sciences
- Government
- NIEHS NIH HHS
- Government
- NCI NIH HHS
- Grants
- National Cancer Institute (R01 CA93780); National Institute of Environmental Health Sciences (P30 ES 003819); National Institute of Environmental Health Sciences (P01 ES006052)
Based on 4 listed funder(s).
Publication
- Published
- 2011-11-01 · Carcinogenesis · vol. 33 · issue 1 · pp. 101–107
- Publisher
- Oxford University Press
- Cited
- 130 citations · more than 94% of similar papers · 3.7× the field average
- Impact
- Top 10% most cited in its field
- References
- 54 works
- Access
- Open access (repository copy)
- Research areas
- Genomics, phytochemicals, and oxidative stress · Free Radicals and Antioxidants · Tryptophan and brain disorders
- Keywords
- Sulforaphane, Glucoraphanin, Cruciferous vegetables, Glucosinolate, Mercapturic acid, Food science, Excretion, Chemistry, Glutathione, Brassica, Crossover study, Toxicology, Medicine, Biochemistry, Botany, Internal medicine, Biology
- MeSH
- humans, brassica, aldehydes, acrolein, oximes, thiocyanates, ethylene oxide, benzene, imidoesters, isothiocyanates, sulfoxides, glucosinolates, acetylcysteine, dna adducts, air pollutants, smoking, beverages, adult, middle aged, china, female, male, biomarkers, polycyclic aromatic hydrocarbons
15 authors
From US, CN
- Thomas W. Kensler · correspondingJohns Hopkins University; University of Pittsburgh; Johns Hopkins Medicine
- Derek K. NgJohns Hopkins University
- Steven G. CarmellaUniversity of Minnesota Medical Center
- Menglan ChenUniversity of Minnesota Medical Center
- Lisa P. JacobsonJohns Hopkins University
- Álvaro MuñozJohns Hopkins University
Abstract
Epidemiological evidence has suggested that consumption of a diet rich in cruciferous vegetables reduces the risk of several types of cancers and chronic degenerative diseases. In particular, broccoli sprouts are a convenient and rich source of the glucosinolate, glucoraphanin, which can release the chemopreventive agent, sulforaphane, an inducer of glutathione S-transferases. Two broccoli sprout-derived beverages, one sulforaphane-rich (SFR) and the other glucoraphanin-rich (GRR), were evaluated for pharmacodynamic action in a crossover clinical trial design. Study participants were recruited from the farming community of He Zuo Township, Qidong, China, previously documented to have a high incidence of hepatocellular carcinoma with concomitant exposures to aflatoxin and more recently characterized with exposures to substantive levels of airborne pollutants. Fifty healthy participants were randomized into two treatment arms. The study protocol was as follows: a 5 days run-in period, a 7 days administration of beverage, a 5 days washout period and a 7 days administration of the opposite beverage. Urinary excretion of the mercapturic acids of acrolein, crotonaldehyde, ethylene oxide and benzene were measured both pre- and postinterventions using liquid chromatography tandem mass spectrometry. Statistically significant increases of 20-50% in the levels of excretion of glutathione-derived conjugates of acrolein, crotonaldehyde and benzene were seen in individuals receiving SFR, GRR or both compared with their preintervention baseline values. No significant differences were seen between the effects of SFR versus GRR. Intervention with broccoli sprouts may enhance detoxication of airborne pollutants and attenuate their associated health risks.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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