Funded in part by Nestlé Nutrition Institute
Short-term use of parenteral nutrition with a lipid emulsion containing a mixture of soybean oil, olive oil, medium-chain triglycerides, and fish oil: a randomized double-blind study in preterm infants
Rayyan M, Devlieger H, Jochum F, Allegaert K
JPEN. Journal of parenteral and enteral nutrition · 103 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Food provided by researchers
Who paid for it
- Funding
- Industry funded
- Company
- Nestlé Nutrition Institute
- Government
- Vlaamse regering
- Authors
- At least one author declares a financial tie to industry
Based on 2 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2012-01-01 · JPEN J Parenter Enteral Nutr · vol. 36 · issue 1S · pp. 81S–94S
- Publisher
- Wiley
- Cited
- 147 citations · more than 99% of similar papers · 10.2× the field average
- Impact
- Top 10% most cited in its field
- References
- 71 works
- Access
- Open access (hybrid journal) · CC-BY-NC
- Research areas
- Clinical Nutrition and Gastroenterology · Infant Nutrition and Health · Neonatal Respiratory Health Research
- Keywords
- Fish oil, Soybean oil, Docosahexaenoic acid, Eicosapentaenoic acid, Triglyceride, Parenteral nutrition, Emulsion, Chemistry, Medium-chain triglyceride, Fatty acid, Food science, Animal science, Biochemistry, Polyunsaturated fatty acid, Medicine, Cholesterol, Biology, Internal medicine, Fish <Actinopterygii>
- MeSH
- liver, erythrocytes, humans, soybean oil, fatty acids, triglycerides, phospholipids, fish oils, plant oils, emulsions, treatment outcome, parenteral nutrition, proportional hazards models, double-blind method, infant, newborn, infant, premature, female, male, olive oil
4 authors
From BE, DE
- Maissa Rayyan · correspondingKU Leuven
- Hugo DevliegerKU Leuven
- Frank JochumWaldkrankenhaus Protestant Hospital
- Karel AllegaertKU Leuven
Abstract
Background
For premature neonates needing parenteral nutrition (PN), a balanced lipid supply is crucial. The authors hypothesized that a lipid emulsion containing medium-chain triglycerides (MCTs) and soybean, olive, and fish oils would be as safe and well tolerated as a soybean emulsion while beneficially influencing the fatty acid profile.
Methods
Double-blind, controlled study in 53 neonates (<34 weeks' gestation) randomized to receive at least 7 days of PN containing either an emulsion of MCTs and soybean, olive, and fish oils or a soybean oil emulsion. Target lipid dosage was 1.0 g fat/kg body weight [BW]/d on days 1-3, 2 g/kg BW/d on day 4, 3 g/kg BW/d on day 5, and 3.5 g/kg BW/d on days 6-14.
Results
Test emulsion vs control, mean ± SD: baseline triglyceride concentrations were 0.52 ± 0.16 vs 0.54 ± 0.19 mmol/L and increased similarly in both groups to 0.69 ± 0.38 vs 0.67 ± 0.36 on day 8 of treatment (P = .781 for change). A significantly higher decrease in total and direct bilirubin vs baseline was seen in the test group compared with the control group P < .05 between groups). In plasma and red blood cell phospholipids, eicosapentaenoic acid and docosahexaenoic acid were higher, and the n-6/n-3 fatty acid ratio was lower in the test group (P < .05 vs control).
Conclusions
The lipid emulsion, based on a mixture of MCTs and soybean, olive, and fish oils, was safe and well tolerated by preterm infants while beneficially modulating the fatty acid profile.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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