Red and processed meat consumption and risk of pancreatic cancer: meta-analysis of prospective studies
Larsson SC, Wolk A
British journal of cancer · 165 citations
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- Nonprofit
- Swedish Cancer Foundation
- University or hospital
- Karolinska Institutet
Based on 2 listed funder(s).
Publication
- Published
- 2012-01-01 · Br J Cancer · vol. 106 · issue 3 · pp. 603–607
- Publisher
- Springer Nature
- Cited
- 282 citations · more than 94% of similar papers · 2.6× the field average
- Impact
- Top 10% most cited in its field
- References
- 34 works
- Access
- Open access (hybrid journal) · CC-BY-NC-SA
- Research areas
- Pancreatic and Hepatic Oncology Research · Pancreatitis Pathology and Treatment · Nutrition and Health in Aging
- Keywords
- Pancreatic cancer, Meta-analysis, Medicine, Prospective cohort study, Consumption (sociology), Cancer, Internal medicine, Processed meat, Oncology, Risk factor, Environmental health, Food science, Biology
- MeSH
- animals, cattle, sheep, swine, humans, pancreatic neoplasms, diet surveys, risk factors, prospective studies, meat, meat products, adult, aged, middle aged, united states, japan, europe, female, male, surveys and questionnaires
2 authors
From SE
- Susanna C. Larsson · correspondingKarolinska Institutet
- Alicja WolkKarolinska Institutet
Abstract
Background
Whether red and processed meat consumption is a risk factor for pancreatic cancer remains unclear. We conducted a meta-analysis to summarise the evidence from prospective studies of red and processed meat consumption and pancreatic cancer risk.
Methods
Relevant studies were identified by searching PubMed and EMBASE databases through November 2011. Study-specific results were pooled using a random-effects model.
Results
Eleven prospective studies, with 6643 pancreatic cancer cases, were included in the meta-analysis. An increase in red meat consumption of 120 g per day was associated with an overall relative risk (RR) of 1.13 (95% confidence interval (CI)=0.93-1.39; P(heterogeneity)<0.001). Red meat consumption was positively associated with pancreatic cancer risk in men (RR=1.29; 95% CI=1.08-1.53; P(heterogeneity)=0.28; five studies), but not in women (RR=0.93; 95% CI=0.74-1.16; P(heterogeneity)=0.21; six studies). The RR of pancreatic cancer for a 50 g per day increase in processed meat consumption was 1.19 (95% CI=1.04-1.36; P(heterogeneity)=0.46).
Conclusion
Findings from this meta-analysis indicate that processed meat consumption is positively associated with pancreatic cancer risk. Red meat consumption was associated with an increased risk of pancreatic cancer in men. Further prospective studies are needed to confirm these findings.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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