Intake of red meat and heterocyclic amines, metabolic pathway genes and bladder cancer risk
Lin J, Forman MR, Wang J, Grossman HB, Chen M, Dinney CP, Hawk ET, Wu X
International journal of cancer · 23 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Case-control study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- Government
- National Cancer Institute
- Government
- NCI NIH HHS
- Grants
- National Cancer Institute (R01 CA74880); National Cancer Institute (P50 CA091846); National Cancer Institute (K07 CA134831); National Cancer Institute (R03 CA128079); National Cancer Institute (R01 CA074880)
Based on 2 listed funder(s).
Publication
- Published
- 2012-01-19 · Int J Cancer · vol. 131 · issue 8 · pp. 1892–1903
- Publisher
- Wiley
- Cited
- 33 citations · more than 88% of similar papers · 2.5× the field average
- References
- 52 works
- Access
- Free to read
- Research areas
- Nutritional Studies and Diet · Consumer Attitudes and Food Labeling · Tea Polyphenols and Effects
- Keywords
- Bladder cancer, Gene, Medicine, Cancer, Physiology, Biology, Internal medicine, Endocrinology, Genetics
- MeSH
- humans, amines, heterocyclic compounds, prognosis, risk factors, case-control studies, follow-up studies, genotype, polymorphism, single nucleotide, meat, middle aged, texas, female, male, urinary bladder, urinary bladder neoplasms, cooking, biomarkers, tumor
8 authors
From US
- Jie Ming LinThe University of Texas MD Anderson Cancer Center
- Michele R. FormanThe University of Texas MD Anderson Cancer Center
- Jianming WangThe University of Texas MD Anderson Cancer Center
- Herbert Barton GrossmanThe University of Texas MD Anderson Cancer Center
- Meng ChenThe University of Texas MD Anderson Cancer Center
- Colin P. DinneyThe University of Texas MD Anderson Cancer Center
Abstract
We analyzed the association between meat intake, heterocyclic amines (HCAs) and bladder cancer (BC) risk in a large case-control study comprised of 884 BC cases and 878 healthy controls, recruited from 1999 to 2009. Epidemiologic and dietary data were collected via an in-person interview. Compared to the lowest quartile of red meat intake, the odds ratios (ORs) for the second, third and fourth quartiles were 1.17 (95% CI: 0.87-1.58), 1.47 (95% CI: 1.09-1.99) and 1.95 (95% CI: 1.41-2.68), respectively, (p-for trend <0.001). In a subset of participants with intakes of HCAs available, compared with those with the lowest quartile of intake, the ORs for the second, third and fourth quartiles were 1.47 (95% CI: 0.60-3.64), 2.58 (95% CI: 1.09-6.11) and 3.32 (95% CI: 1.37-8.01), respectively, (p for trend <0.001). In cumulative analysis of SNPs in the pathway, compared with subjects carrying 0-4 unfavorable genotypes, subjects carrying 5 and 6 or more unfavorable genotypes were at 1.60-fold (95% CI: 1.20-2.12) and 2.37-fold (95% CI: 1.82-3.10) increased risk, respectively. Moreover, subjects carrying six or more unfavorable genotypes and whose red meat intake was in the highest quartile were at 5.09-fold increased risk (95% CI: 2.89-8.96; p < 0.001). These results strongly support that high red meat intake, high intake of HCAs and carrying high number of unfavorable genotypes in the HCA metabolic pathways are associated with increased risk of BC in the study population.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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