Funded in part by GlaxoSmithKline
Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans
Ouellet V, Labbé SM, Blondin DP, Phoenix S, Guérin B, Haman F, Turcotte EE, Richard D, Carpentier AC
The Journal of clinical investigation · 793 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Controlled clinical trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Industry funded
- Company
- GlaxoSmithKline
- Nonprofit
- Canadian Diabetes Association
- University or hospital
- Université Laval
- University or hospital
- Institut universitaire de cardiologie et de pneumologie de Québec, Université Laval
- Government
- Canadian Institutes of Health Research
- Grants
- Canadian Diabetes Association (OG‐3‐10‐2970‐AC)
Based on 5 listed funder(s).
Publication
- Published
- 2012-01-24 · J Clin Invest · vol. 122 · issue 2 · pp. 545–552
- Publisher
- American Society for Clinical Investigation
- Cited
- 997 citations · more than 100% of similar papers · 47.1× the field average
- Impact
- Top 10% most cited in its field
- References
- 40 works
- Access
- Open access (repository copy)
- Research areas
- Adipose Tissue and Metabolism · Exercise and Physiological Responses · Thermoregulation and physiological responses
- Keywords
- Brown adipose tissue, Thermogenesis, NEFA, Endocrinology, Internal medicine, Oxidative phosphorylation, Adipose tissue, Thermogenin, Biology, Carbohydrate metabolism, Metabolism, Chemistry, Biochemistry, Medicine, Insulin
- MeSH
- animals, humans, fluorodeoxyglucose f18, blood glucose, fatty acids, nonesterified, positron-emission tomography, body temperature, energy metabolism, body temperature regulation, thermogenesis, adult, male, adipose tissue, brown, cold temperature, young adult
9 authors
From CA
- V. OuelletInstitut universitaire de cardiologie et de pneumologie de Québec
- Sébastien M. LabbéUniversité de Sherbrooke
- Denis P. BlondinMontfort Hospital
- Serge PhoenixUniversité de Sherbrooke
- Brigitte GuérinUniversité de Sherbrooke
- François HamanMontfort Hospital
Abstract
Brown adipose tissue (BAT) is vital for proper thermogenesis during cold exposure in rodents, but until recently its presence in adult humans and its contribution to human metabolism were thought to be minimal or insignificant. Recent studies using PET with 18F-fluorodeoxyglucose (18FDG) have shown the presence of BAT in adult humans. However, whether BAT contributes to cold-induced nonshivering thermogenesis in humans has not been proven. Using PET with 11C-acetate, 18FDG, and 18F-fluoro-thiaheptadecanoic acid (18FTHA), a fatty acid tracer, we have quantified BAT oxidative metabolism and glucose and nonesterified fatty acid (NEFA) turnover in 6 healthy men under controlled cold exposure conditions. All subjects displayed substantial NEFA and glucose uptake upon cold exposure. Furthermore, we demonstrated cold-induced activation of oxidative metabolism in BAT, but not in adjoining skeletal muscles and subcutaneous adipose tissue. This activation was associated with an increase in total energy expenditure. We found an inverse relationship between BAT activity and shivering. We also observed an increase in BAT radio density upon cold exposure, indicating reduced BAT triglyceride content. In sum, our study provides evidence that BAT acts as a nonshivering thermogenesis effector in humans.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.