Funded in part by Nestec
What is the cell hydration status of healthy children in the USA? Preliminary data on urine osmolality and water intake
Stookey JD, Brass B, Holliday A, Arieff A
Public health nutrition · 67 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cross-sectional study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Industry funded
- Company
- Nestec
Based on 1 listed funder(s).
Publication
- Published
- 2012-01-27 · Public Health Nutr · vol. 15 · issue 11 · pp. 2148–2156
- Publisher
- Cambridge University Press
- Cited
- 86 citations · more than 96% of similar papers · 4.9× the field average
- Impact
- Top 10% most cited in its field
- References
- 82 works
- Access
- Free to read
- Research areas
- Thermoregulation and physiological responses · Electrolyte and hormonal disorders · Therapeutic Uses of Natural Elements
- Keywords
- Urine osmolality, Urine, Morning, Urine sample, Medicine, Logistic regression, Osmotic concentration, Environmental health, Demography, Internal medicine
- MeSH
- humans, dehydration, water, multivariate analysis, logistic models, cross-sectional studies, health status, osmosis, drinking, osmolar concentration, beverages, child, new york city, los angeles, female, male, cell physiological phenomena, stress, physiological, self report, breakfast
4 authors
From US
- Jodi Dunmeyer Stookey · corresponding
- Bernie Brass
- Ava Holliday
- Allen I. ArieffUniversity of California, San Francisco
Abstract
Objective
Hyperosmotic stress on cells limits many aspects of cell function, metabolism and health. International data suggest that schoolchildren may be at risk of hyperosmotic stress on cells because of suboptimal water intake. The present study explored the cell hydration status of two samples of children in the USA.
Design
Cross-sectional study describing the urine osmolality (an index of hyperosmotic cell shrinkage) and water intake of convenience samples from Los Angeles (LA) and New York City (NYC).
Setting
Each participant collected a urine sample at an outpatient clinic on the way to school on a weekday morning in spring 2009. Each was instructed to wake, eat, drink and do as usual before school, and complete a dietary record form describing the type and amounts of all foods and beverages consumed after waking, before giving the sample.
Subjects
The children (9-11 years) in LA (n 337) and NYC (n 211) considered themselves healthy enough to go to school on the day they gave the urine sample.
Results
Elevated urine osmolality (>800 mmol/kg) was observed in 63 % and 66 % of participants in LA and NYC, respectively. In multivariable-adjusted logistic regression models, elevated urine osmolality was associated with not reporting intake of drinking water in the morning (LA: OR = 2·1, 95 % CI 1·2, 3·5; NYC: OR = 1·8, 95 % CI 1·0, 3·5). Although over 90 % of both samples had breakfast before giving the urine sample, 75 % did not drink water.
Conclusions
Research is warranted to confirm these results and pursue their potential health implications.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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