Fixed-drug eruption caused by ashwagandha (Withania somnifera): a widely used Ayurvedic drug
Sehgal VN, Verma P, Bhattacharya SN
Skinmed · 3 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Case report (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2012-02-23 · Skinmed · vol. 10 · issue 1 · pp. 48–9
- Publisher
- National Institutes of Health
- Cited
- 3 citations · more than 33% of similar papers · 0.0× the field average
- References
- 0 works
- Access
- Paywalled
- Research areas
- Drug-Induced Adverse Reactions · Chemotherapy-related skin toxicity · Contact Dermatitis and Allergies
- Keywords
- Medicine, Glans penis, Penis, Itching, Dermatology, Withania somnifera, Drug, Clobetasol propionate, Drug eruption, Provocation test, Pharmacology, Surgery, Psoriasis, Pathology
- MeSH
- humans, withania, penile diseases, drug eruptions, cetirizine, clobetasol, plant extracts, medicine, ayurvedic, phytotherapy, adult, male
3 authors
- Virendra Nath Sehgal
- Prashant R. Verma
- Sambit Nath Bhattacharya
Abstract
A 28-year-old man with decreased libido received ashwagandha in the usual daily dosage of 5 g for 10 days. During this period, he experienced a burning and/or itching sensation as well as discoloration of the skin/mucous membrane confined to the penis. He had a similar type of eruption at the same site 6 months prior while taking ashwagandha. Examination of the skin surface was conspicuous and marked by the presence of a dusky, erythematous, oval, eroded plaque of 3 cm, affecting the glans penis and prepuce (Figure). The drug was withdrawn and topical 0.05% clobetasol propionate cream was administered along with cetrizine dihydrochloride, an H1-receptor blocker, 10 mg daily for 1 month. There was a perceptible amelioration of the lesion, resulting in residual greyish white pigmentation. He was prescribed oral drug provocation with 1 g of ashwagandha powder. Within 12 hours, a flare-up developed at the earlier site, confirming the causality.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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