Dietary nitrate and nitrite intake and non-Hodgkin lymphoma survival
Aschebrook-Kilfoy B, Ward MH, Zheng T, Holford TR, Boyle P, Leaderer B, Zhang Y
Nutrition and cancer · 8 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Case-control study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- Government
- State of Connecticut Department of Public Health
- University or hospital
- Yale Cancer Center
- University or hospital
- Georgia Clinical and Translational Science Alliance
- Government
- National Cancer Institute
- Government
- Fogarty International Center
- Government
- National Center for Research Resources
- Government
- FIC NIH HHS
- Government
- NCI NIH HHS
- Government
- NCRR NIH HHS
- Grants
- National Center for Research Resources (UL1-RR024139); Fogarty International Center (1D43TW008323-01); National Cancer Institute (R01 CA062006); Fogarty International Center (D43TW 008323); Fogarty International Center (D43 TW007864); Fogarty International Center (1D43TW007864-01)
Based on 9 listed funder(s).
Publication
- Published
- 2012-03-16 · Nutr Cancer · vol. 64 · issue 3 · pp. 488–492
- Publisher
- Routledge
- Cited
- 10 citations · more than 63% of similar papers · 0.4× the field average
- References
- 21 works
- Access
- Open access (repository copy)
- Research areas
- Viral-associated cancers and disorders · Bladder and Urothelial Cancer Treatments · RNA modifications and cancer
- Keywords
- Nitrite, Nitrate, Medicine, Lymphoma, Internal medicine, Gastroenterology, Dietary Nitrate, Follicular lymphoma, Cancer, Population, Immunology, Biology, Environmental health, Ecology
- MeSH
- humans, lymphoma, non-hodgkin, nitrates, nitrites, diet, multivariate analysis, risk factors, case-control studies, follow-up studies, adult, aged, aged, 80 and over, middle aged, connecticut, female, young adult
7 authors
From US, FR
- Briseis Aschebrook‐KilfoyChicago Department of Public Health; University of Chicago
- Mary H. WardNational Institutes of Health; National Cancer Institute
- Tongzhang ZhengYale University
- Theodore R. HolfordYale University
- Peter A. BoyleInternational Prevention Research Institute
- Brian P. LeadererYale University
Abstract
Nitrate and nitrite are precursors in the formation of N-nitroso compounds. We recently found a 40% increased risk of NHL with higher dietary nitrite intake and significant increases in risk for follicular and T-cell lymphoma. It is possible that these compounds also affect NHL prognosis by enhancing cancer progression in addition to development by further impairing immune system function. To test the hypothesis that nitrate and nitrite intake affects NHL survival, we evaluated the association in study participants that have been followed post-disease diagnosis in a population-based case-control study among women in Connecticut. We did not observe a significant increasing trend of mortality for NHL overall or by subtype for nitrate or nitrite intake for deaths from NHL or death from any cause, although a borderline significant protective trend was observed for follicular lymphoma with increasing nitrate intake. We did not identify a difference in overall survival for nitrate (P = 0.39) or for nitrite (P = 0.66) or for NHL specific survival for nitrate (P = 0.96) or nitrite (P = 0.17). Thus, our null findings do not confer support for the possibility that dietary nitrate and nitrite intake impacts NHL survival by promoting immune unresponsiveness.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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