Consumption of red meat and whole-grain bread in relation to biomarkers of obesity, inflammation, glucose metabolism and oxidative stress
Montonen J, Boeing H, Fritsche A, Schleicher E, Joost HG, Schulze MB, Steffen A, Pischon T
European journal of nutrition · 154 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Independent funding
- Government
- Bundesministerium für Bildung und Forschung
- Grants
- Bundesministerium für Bildung und Forschung (0315381A)
Based on 1 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2012-03-17 · Eur J Nutr · vol. 52 · issue 1 · pp. 337–345
- Publisher
- Springer Science+Business Media
- Cited
- 233 citations · more than 100% of similar papers · 17.4× the field average
- Impact
- Top 10% most cited in its field
- References
- 62 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Nutritional Studies and Diet · Meat and Animal Product Quality · Agriculture Sustainability and Environmental Impact
- Keywords
- Glycated hemoglobin, Red meat, Adiponectin, Medicine, Waist, Internal medicine, Obesity, Body mass index, Anthropometry, European Prospective Investigation into Cancer and Nutrition, Diabetes mellitus, Endocrinology, Food science, Type 2 diabetes, Insulin resistance, Biology
- MeSH
- animals, cattle, humans, cardiovascular diseases, obesity, inflammation, gamma-glutamyltransferase, alanine transaminase, blood glucose, triglycerides, c-reactive protein, body mass index, diet, prospective studies, cross-sectional studies, life style, oxidative stress, bread, meat, middle aged, female, male, adiponectin, cholesterol, hdl, waist circumference, alpha-2-hs-glycoprotein, biomarkers, surveys and questionnaires, edible grain, glycated hemoglobin
8 authors
From DE
- Jukka MontonenGerman Institute of Human Nutrition
- Heiner BoeingGerman Institute of Human Nutrition
- Andreas FritscheUniversity of Tübingen
- Erwin D. SchleicherUniversity of Tübingen
- Hans‐Georg JoostGerman Institute of Human Nutrition
- Matthias Bernd SchulzeGerman Institute of Human Nutrition
Abstract
Purpose
To examine the association of red meat and whole-grain bread consumption with plasma levels of biomarkers related to glucose metabolism, oxidative stress, inflammation and obesity.
Methods
Our cross-sectional study was based on 2,198 men and women who were selected as a sub-cohort for an investigation of biological predictors of diabetes and cardiovascular diseases from the European Prospective Investigation into Cancer and Nutrition-Potsdam study. Circulating levels of glycated hemoglobin, adiponectin, hs-CRP, gamma-glutamyltransferase, alanine-aminotransferase, fetuin-A, HDL-cholesterol and triglycerides were measured from random blood samples. Diet and lifestyle data were assessed by questionnaires, and anthropometric data were measured.
Results
After multivariable adjustment, higher consumption of whole-grain bread was significantly (P trend <0.05) associated with lower levels of GGT, ALT and hs-CRP, whereas higher consumption of red meat was significantly associated with higher levels of GGT and hs-CRP when adjusted for potential confounding factors related to lifestyle and diet. Further adjustment for body mass index and waist circumference attenuated the association between red meat and hs-CRP (P = 0.19).
Conclusions
The results of this study suggest that high consumption of whole-grain bread is related to lower levels of GGT, ALT and hs-CRP, whereas high consumption of red meat is associated with higher circulating levels of GGT and hs-CRP.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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