The safety of cruciferous plants in humans: a systematic review
Scott O, Galicia-Connolly E, Adams D, Surette S, Vohra S, Yager JY
Journal of biomedicine & biotechnology · 7 citations
How it was studied
- Design
- Systematic review (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- Nonprofit
- Heart and Stroke Foundation of Canada
- Nonprofit
- Alva Foundation
Based on 2 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2012-01-01 · J Biomed Biotechnol · vol. 2012 · pp. 1–28
- Publisher
- Hindawi Publishing Corporation
- Cited
- 21 citations · more than 16% of similar papers · 0.1× the field average
- References
- 83 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Genomics, phytochemicals, and oxidative stress · Vitamin C and Antioxidants Research · Herbal Medicine Research Studies
- Keywords
- Cruciferous vegetables, Adverse effect, Medicine, Observational study, Internal medicine, Cancer
- MeSH
- humans, brassicaceae, plant extracts
6 authors
From CA
- Ori ScottUniversity of Alberta; Stollery Children's Hospital
- Elaine Galicia-ConnollyUniversity of Alberta Hospital
- Denise L. C. AdamsUniversity of Alberta Hospital
- Soleil SuretteUniversity of Alberta Hospital
- Sunita VohraUniversity of Alberta; University of Alberta Hospital
- Jerome Y. Yager · correspondingUniversity of Alberta; Stollery Children's Hospital
Abstract
Some cruciferous plants may serve as preventive treatments for several medical conditions; our objective was to systematically investigate their safety in humans. Four electronic databases were searched, and, of 10,831 references identified, 50 were included. Data were extracted by two independent reviewers, whereafter the association between interventions and adverse events was assessed. Adverse events in 53 subjects were identified through clinical trials; of these, altered drug metabolism was rated as certainly/likely caused by cruciferous plants. Adverse events in 1247 subjects were identified through observational studies, of which none received high causality ratings. Adverse events in 35 subjects were identified through case reports, of which allergies and warfarin resistance were rated as certainly/likely caused by cruciferous plants. We conclude that cruciferous plants are safe in humans, with the exception of allergies. Individuals treated with warfarin should consult their physician. Further investigation of uses of cruciferous plants in preventative medicine is warranted.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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