Effect of broccoli sprouts on insulin resistance in type 2 diabetic patients: a randomized double-blind clinical trial
Bahadoran Z, Tohidi M, Nazeri P, Mehran M, Azizi F, Mirmiran P
International journal of food sciences and nutrition · 133 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- University or hospital
- Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences
Based on 1 listed funder(s).
Publication
- Published
- 2012-04-26 · Int J Food Sci Nutr · vol. 63 · issue 7 · pp. 767–771
- Publisher
- Taylor & Francis
- Cited
- 210 citations · more than 94% of similar papers · 3.5× the field average
- Impact
- Top 10% most cited in its field
- References
- 21 works
- Access
- Paywalled
- Research areas
- Genomics, phytochemicals, and oxidative stress · Natural Antidiabetic Agents Studies · Phytochemicals and Antioxidant Activities
- Keywords
- Insulin resistance, Type 2 diabetes, Internal medicine, Medicine, Placebo, Insulin, Diabetes mellitus, Endocrinology, Randomized controlled trial, Homeostasis, Double blind, Gastroenterology
- MeSH
- humans, brassica, plant shoots, diabetes mellitus, type 2, hyperglycemia, hyperinsulinism, insulin resistance, isothiocyanates, sulfoxides, insulin, blood glucose, antioxidants, double-blind method, patient compliance, dietary supplements, adult, middle aged, patient dropouts, iran, female, male
6 authors
From IR
- Zahra BahadoranResearch Institute for Endocrine Sciences; Shahid Beheshti University of Medical Sciences
- Maryam TohidiResearch Institute for Endocrine Sciences; Shahid Beheshti University of Medical Sciences
- Pantea NazeriResearch Institute for Endocrine Sciences; Shahid Beheshti University of Medical Sciences
- Mahya MehranResearch Institute for Endocrine Sciences; Shahid Beheshti University of Medical Sciences
- Fereidoun AziziResearch Institute for Endocrine Sciences; Shahid Beheshti University of Medical Sciences
- Parvin Mirmiran · correspondingNational Nutrition and Food Technology Research Institute; Shahid Beheshti University of Medical Sciences
Abstract
Use of antioxidant components is a new approach for improvement of insulin resistance (IR) as a main feature of type 2 diabetes and its complications. The aim of this study was to investigate the effects of broccoli sprouts powder (BSP) containing high concentration of sulphoraphane on IR in type 2 diabetic patients. Eighty-one patients were randomly assigned to receive 10 g/d BSP (A, n = 27), 5 g/d BSP (B, n = 29) and placebo (C, n = 25) for 4 weeks. Fasting serum glucose and insulin concentration, glucose to insulin ratio and homoeostasis model assessment of IR (HOMA-IR) index were measured at baseline and again 4 weeks after treatment. Seventy-two patients completed the study and 63 were included in the analysis. After 4 weeks, consumption of 10 g/d BSP resulted in a significant decrease in serum insulin concentration and HOMA-IR (p = 0.05 for treatment effect). Therefore, broccoli sprouts may improve IR in type 2 diabetic patients.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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