Inhibition of estrogen-mediated mammary tumorigenesis by blueberry and black raspberry
Ravoori S, Vadhanam MV, Aqil F, Gupta RC
Journal of agricultural and food chemistry · 44 citations
How it was studied
- Design
- Animal study (classified by our AI screen)
- Studied in
- Animals
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
- Government
- National Cancer Institute
- Government
- NCI NIH HHS
- Grants
- National Cancer Institute (CA-125152); National Cancer Institute (CA-118114)
Based on 2 listed funder(s).
Publication
- Published
- 2012-05-09 · J Agric Food Chem · vol. 60 · issue 22 · pp. 5547–5555
- Publisher
- American Chemical Society
- Cited
- 60 citations · more than 84% of similar papers · 1.9× the field average
- References
- 73 works
- Access
- Paywalled
- Research areas
- Phytochemicals and Antioxidant Activities · Pomegranate: compositions and health benefits · Genomics, phytochemicals, and oxidative stress
- Keywords
- Ellagic acid, Phytochemical, Mammary tumor, Estrogen, Carcinogenesis, Biology, Pharmacology, Chemistry, Medicine, Endocrinology, Internal medicine, Cancer, Traditional medicine, Antioxidant, Biochemistry, Polyphenol, Breast cancer
- MeSH
- animals, rats, inbred aci, humans, rats, rosaceae, fruit, breast neoplasms, cell transformation, neoplastic, plant extracts, antineoplastic agents, phytogenic, estrogens, down-regulation, female, blueberry plants
4 authors
From US
- Srivani RavooriUniversity of Louisville; James Graham Brown Foundation
- Manicka V. VadhanamUniversity of Louisville; James Graham Brown Foundation
- Farrukh AqilUniversity of Louisville; James Graham Brown Foundation
- Ramesh Chand Gupta · correspondingUniversity of Louisville; James Graham Brown Foundation
Abstract
We previously demonstrated the protective effects of blueberry (BB) and black raspberry (BRB) supplemented at 2.5% dose in an ACI rat mammary tumor model. Here, we assessed a dose-related alteration in tumor indices with diet supplemented with 5% BB or BRB powder. The diet was well tolerated. Tumor palpation from 12 weeks revealed first tumor appearance by 84 days in the control group, that was delayed by 24 and 39 days with the BB and BRB diets, respectively (p = 0.04). Ellagic acid detected in the plasma of rats fed the BRB diet was in the range of 96.6-294.2 ng/mL. While the BB diet showed better efficacy in reducing mammary tissue proliferation and tumor burden, tumor latency was delayed efficiently by BRB. Furthermore, BB was effective in downregulating CYP1A1 expression, while BRB downregulated ERα expression effectively. Distinct anticarcinogenic effects of the two berries correspond to their distinct phytochemical signatures.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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