Diets containing pistachios reduce systolic blood pressure and peripheral vascular responses to stress in adults with dyslipidemia
West SG, Gebauer SK, Kay CD, Bagshaw DM, Savastano DM, Diefenbach C, Kris-Etherton PM
Hypertension (Dallas, Tex. : 1979) · 43 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Food provided by researchers
Who paid for it
- Funding
- Independent funding
- University or hospital
- Pennsylvania State University
- Government
- National Center for Research Resources
- Government
- National Center for Advancing Translational Sciences
- Government
- NCATS NIH HHS
- Government
- NCRR NIH HHS
- Grants
- National Center for Advancing Translational Sciences (UL1-TR000127); National Center for Research Resources (M01-RR-010732)
Based on 5 listed funder(s).
Publication
- Published
- 2012-06-05 · Hypertension · vol. 60 · issue 1 · pp. 58–63
- Publisher
- Lippincott Williams & Wilkins
- Cited
- 56 citations · more than 95% of similar papers · 4.4× the field average
- Impact
- Top 10% most cited in its field
- References
- 34 works
- Access
- Free to read
- Research areas
- Nuts composition and effects · Nutritional Studies and Diet · Antioxidant Activity and Oxidative Stress
- Keywords
- Blood pressure, Saturated fat, Medicine, Crossover study, Heart rate, Internal medicine, Endocrinology, Calorie, Vascular resistance, Animal science, Cardiology, Cholesterol, Biology, Placebo
- MeSH
- brachial artery, humans, pistacia, ultrasonography, cardiac output, diet, fat-restricted, fasting, cross-over studies, blood pressure, heart rate, vascular resistance, dose-response relationship, drug, adult, dyslipidemias, stress, physiological, outcome assessment, health care
7 authors
From GB, US
- Sheila G. WestUniversity of East Anglia; GlaxoSmithKline (United States); Beltsville Agricultural Research Center; New York University
- Sarah K GebauerUniversity of East Anglia; GlaxoSmithKline (United States); Beltsville Agricultural Research Center; New York University
- Colin D. KayUniversity of East Anglia; GlaxoSmithKline (United States); Beltsville Agricultural Research Center; New York University
- Deborah Maddox BagshawUniversity of East Anglia; GlaxoSmithKline (United States); Beltsville Agricultural Research Center; New York University
- David M. SavastanoUniversity of East Anglia; GlaxoSmithKline (United States); Beltsville Agricultural Research Center; New York University
- Christopher DiefenbachUniversity of East Anglia; GlaxoSmithKline (United States); Beltsville Agricultural Research Center; New York University
Abstract
Nut consumption reduces cardiovascular risk, and reductions in blood pressure and peripheral vascular resistance may be important mediators of this relationship. We evaluated effects of pistachios on flow-mediated dilation and blood pressure response to acute stress. Twenty-eight adults with dyslipidemia completed a randomized, crossover, controlled-feeding study. All of the meals were provided and calories were controlled. After 2 weeks on a typical Western diet (35% total fat and 11% saturated fat), test diets were presented in counterbalanced order for 4 weeks each, a low-fat control diet (25% total fat and 8% saturated fat), a diet containing 10% of energy from pistachios (on average, 1 serving per day; 30% total fat and 8% saturated fat), and a diet containing 20% of energy from pistachios (on average, 2 servings per day, 34% total fat and 8% saturated fat). None of the resting hemodynamic measures significantly differed from pretreatment values. When resting and stress levels were included in the repeated-measures analysis, average reductions in systolic blood pressure were greater after the diet containing 1 serving per day versus 2 servings per day of pistachios (mean change in systolic blood pressure, -4.8 vs -2.4 mm Hg, respectively; P<0.05). After the higher dose, there were significant reductions in peripheral resistance (-62.1 dyne · s × cm(-5)) and heart rate (-3 bpm) versus the control diet (P<0.0001). These changes were partially offset by increases in cardiac output. There was no effect of diet on fasting flow-mediated dilation. Reductions in peripheral vascular constriction and the resulting decrease in hemodynamic load may be important contributors to lower risk in nut consumers.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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