Thyroid cancer risk and dietary nitrate and nitrite intake in the Shanghai women's health study
Aschebrook-Kilfoy B, Shu XO, Gao YT, Ji BT, Yang G, Li HL, Rothman N, Chow WH, Zheng W, Zheng W, Ward MH
International journal of cancer · 43 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Independent funding
- Government
- National Institutes of Health
- Government
- National Cancer Institute
- Government
- NCI NIH HHS
- Government
- Intramural NIH HHS
- Grants
- National Cancer Institute (R01 CA 070867); National Cancer Institute (N02-CP-11010-66); National Cancer Institute (R01 CA70867); National Cancer Institute (R37-CA070867); National Institutes of Health (Z01 CP010153)
Based on 4 listed funder(s).
Publication
- Published
- 2012-06-02 · Int J Cancer · vol. 132 · issue 4 · pp. 897–904
- Publisher
- Wiley
- Cited
- 71 citations · more than 89% of similar papers · 2.3× the field average
- References
- 35 works
- Access
- Open access (repository copy)
- Research areas
- Thyroid Disorders and Treatments · Nutritional Studies and Diet · Thyroid Cancer Diagnosis and Treatment
- Keywords
- Nitrite, Nitrate, Quartile, Medicine, Confidence interval, Relative risk, Thyroid cancer, Body mass index, Internal medicine, Cancer, Endocrinology, Thyroid, Physiology, Animal science, Chemistry, Biology
- MeSH
- humans, thyroid neoplasms, nitrates, nitrites, nitroso compounds, diet, risk factors, food analysis, eating, meat, meat products, aged, middle aged, women's health, china, female, surveys and questionnaires
10 authors
From US, CN
- Briseis Aschebrook‐KilfoyUniversity of Chicago
- Xiao‐Ou ShuVanderbilt University
- Yu‐Tang GaoShanghai Cancer Institute
- Bu‐Tian JiUniversity of Chicago
- Gong YangVanderbilt University
- Hong Lan LiShanghai Cancer Institute
Abstract
Nitrate and nitrite are precursors in the endogenous formation of N-nitroso compounds and nitrate can disrupt thyroid homeostasis by inhibiting iodide uptake. We evaluated nitrate and nitrite intake and risk of thyroid cancer in the Shanghai Women's Health Study that included 73,317 women, aged 40-70 years enrolled in 1996-2000. Dietary intake was assessed at baseline using a food frequency questionnaire. During approximately 11 years of follow-up, 164 incident thyroid cancer cases with complete dietary information were identified. We used Cox proportional hazards regression to estimate relative risks (RRs). We determined the nitrate and nitrite contents of foods using values from the published literature and focusing on regional values for Chinese foods. Nitrate intake was not associated with thyroid cancer risk [RR(Q4) = 0.93; 95% confidence interval (CI): 0.42-2.07; p for trend = 0.40]. Compared to the lowest quartile, women with the highest dietary nitrite intake had about a twofold risk of thyroid cancer (RR(Q4) = 2.05; 95%CI: 1.20-3.51), but there was not a monotonic trend with increasing intake (p for trend = 0.36). The trend with increasing nitrite intake from animal sources was significant (p for trend = 0.02) and was stronger for nitrite from processed meats (RR(Q4) = 1.96; 95%CI: 1.28-2.99; p for trend < 0.01). Although we did not observe an association for nitrate as hypothesized, our results suggest that women consuming higher levels of nitrite from animal sources, particularly from processed meat, may have an increased risk of thyroid cancer.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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