Effect of a wild blueberry (Vaccinium angustifolium) drink intervention on markers of oxidative stress, inflammation and endothelial function in humans with cardiovascular risk factors
Riso P, Klimis-Zacas D, Del Bo' C, Martini D, Campolo J, Vendrame S, Møller P, Loft S, De Maria R, Porrini M
European journal of nutrition · 181 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Mechanisms only
- Intake measured by
- Not stated
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2012-06-25 · Eur J Nutr · vol. 52 · issue 3 · pp. 949–961
- Publisher
- Springer Science+Business Media
- Cited
- 259 citations · more than 99% of similar papers · 9.3× the field average
- Impact
- Top 10% most cited in its field
- References
- 57 works
- Access
- Open access (repository copy) · OTHER-OA
- Research areas
- Phytochemicals and Antioxidant Activities · Bioactive Compounds in Plants · Pomegranate: compositions and health benefits
- Keywords
- Oxidative stress, Vaccinium, Inflammation, Medicine, Endothelial dysfunction, Traditional medicine, Food science, Biology, Botany, Internal medicine
- MeSH
- endothelium, vascular, humans, fruit, cardiovascular diseases, dna damage, cinnamates, pyrimidines, flavonoids, purines, antioxidants, risk factors, cross-over studies, oxidation-reduction, oxidative stress, beverages, adult, middle aged, italy, male, biomarkers, blueberry plants
10 authors
From IT, US, DK
- Patrizia Riso · correspondingUniversity of Milan
- Dorothy J. Klimis‐ZacasUniversity of Maine
- Cristian Del Bo’University of Milan
- Daniela MartiniUniversity of Milan
- Jonica CampoloAzienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda; Istituto di Fisiologia Clinica
- Stefano VendrameUniversity of Maine
Abstract
Purpose
Wild blueberries (WB) (Vaccinium angustifolium) are rich sources of polyphenols, such as flavonols, phenolic acids and anthocyanins (ACNs), reported to decrease the risk of cardiovascular and degenerative diseases. This study investigated the effect of regular consumption of a WB or a placebo (PL) drink on markers of oxidative stress, inflammation and endothelial function in subjects with risk factors for cardiovascular disease.
Methods
Eighteen male volunteers (ages 47.8 ± 9.7 years; body mass index 24.8 ± 2.6 kg/m²) received according to a cross-over design, a WB (25 g freeze-dried powder, providing 375 mg of ACNs) or a PL drink for 6 weeks, spaced by a 6-week wash-out. Endogenous and oxidatively induced DNA damage in blood mononuclear cells, serum interleukin levels, reactive hyperemia index, nitric oxide, soluble vascular adhesion molecule concentration and other variables were analyzed.
Results
Wild blueberry drink intake significantly reduced the levels of endogenously oxidized DNA bases (from 12.5 ± 5.6 % to 9.6 ± 3.5 %, p ≤ 0.01) and the levels of H₂O₂-induced DNA damage (from 45.8 ± 7.9 % to 37.2 ± 9.1 %, p ≤ 0.01), while no effect was found after the PL drink. No significant differences were detected for markers of endothelial function and the other variables under study.
Conclusions
In conclusion, the consumption of the WB drink for 6 weeks significantly reduced the levels of oxidized DNA bases and increased the resistance to oxidatively induced DNA damage. Future studies should address in greater detail the role of WB in endothelial function.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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