Assessment of Helicobacter pylori eradication by virgin olive oil
Castro M, Romero C, de Castro A, Vargas J, Medina E, Millán R, Brenes M
Helicobacter · 18 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Controlled clinical trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Food provided by researchers
Who paid for it
- Funding
- Independent funding
- Government
- Junta de Andalucía
Based on 1 listed funder(s).
Publication
- Published
- 2012-04-17 · Helicobacter · vol. 17 · issue 4 · pp. 305–311
- Publisher
- Wiley
- Cited
- 34 citations · more than 87% of similar papers · 2.3× the field average
- References
- 24 works
- Access
- Free to read
- Research areas
- Helicobacter pylori-related gastroenterology studies · Consumer Attitudes and Food Labeling · Hibiscus Plant Research Studies
- Keywords
- Helicobacter pylori, Olive oil, Medicine, Urea breath test, Traditional medicine, Helicobacter pylori infection, Internal medicine, Food science, Biology
- MeSH
- humans, helicobacter pylori, helicobacter infections, plant oils, anti-bacterial agents, pilot projects, adult, aged, middle aged, female, male, young adult, olive oil
7 authors
From ES
- Manuel Castro de MouraHospital Universitario de Valme
- Concepción Romero · correspondingInstituto de la Grasa
- Antonio de CastroInstituto de la Grasa
- Julio VargasHospital Universitario de Valme
- Eduardo MedinaInstituto de la Grasa
- Raquel MillánHospital Universitario de Valme
Abstract
Background
A recent study conducted by Medina et al. disclosed that virgin olive oil has a bactericidal effect in vitro against Helicobacter pylori because of its contents of certain phenolic compounds with dialdehydic structures. We carried out two clinical trials to evaluate the effect of virgin olive oil on H. pylori-infected individuals.
Materials and methods
Two different pilot studies were performed with 60 H. pylori-infected adults. In the first study, thirty subjects who tested positive for H. pylori received 30 g of washed virgin olive oil for 14 days, and after 1 month, the patients took 30 g of unwashed virgin olive oil for another 14 days. In a second study, a group of 30 subjects received 30 g of a different virgin olive oil for 14 days. Helicobacter pylori-infection status was checked by the urea breath test.
Results
Helicobacter pylori was eradicated in 8 of 30 individuals when microorganism status was checked after 4-6 weeks from the first clinical intervention although 12 of 30 individuals did not show H. pylori infection at 24-72 hour of the last oil dose. Eradication rates were 27 and 40% by intention to treat and per protocol, respectively. Moreover, only 3 of 30 individuals were H. pylori negative after 4-6 weeks from the second clinical intervention but 5 of 30 were negative at 24-72 hour of the last oil dose. Eradication rates were 10 and 11% by intention to treat and per protocol, respectively. It must also be noted that 13 subjects withdrew from the studies because of taste and nausea drawbacks.
Conclusions
The administration of virgin olive oil showed moderate effectiveness in eradicating H. pylori. Further studies are needed to confirm these findings, especially with longer periods, different administration conditions, and several types of olive oils.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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