Funded in part by Novo Nordisk Fonden
High intakes of protein and processed meat associate with increased incidence of type 2 diabetes
Ericson U, Sonestedt E, Gullberg B, Hellstrand S, Hindy G, Wirfält E, Orho-Melander M
The British journal of nutrition · 86 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Food diaries or recalls
Who paid for it
- Funding
- Industry funded
- Company
- Novo Nordisk Fonden
- Government
- Medical Research Council
Based on 2 listed funder(s).
Publication
- Published
- 2012-08-01 · Br J Nutr · vol. 109 · issue 6 · pp. 1143–1153
- Publisher
- Cambridge University Press
- Cited
- 119 citations · more than 94% of similar papers · 3.7× the field average
- Impact
- Top 10% most cited in its field
- References
- 48 works
- Access
- Free to read
- Research areas
- Diet and metabolism studies · Nutritional Studies and Diet · Nutrition, Genetics, and Disease
- Keywords
- Medicine, Type 2 diabetes, Diabetes mellitus, Hazard ratio, Incidence (geometry), Cohort study, Cohort, Population, Internal medicine, Animal science, Endocrinology, Biology, Confidence interval, Environmental health
- MeSH
- animals, humans, diabetes mellitus, type 2, dietary carbohydrates, dietary fats, dietary proteins, body mass index, exercise, diet, risk factors, cohort studies, prospective studies, body composition, dietary fiber, meat products, aged, middle aged, educational status, female, male, waist circumference
7 authors
From SE
- Ulrika Ericson · correspondingLund University
- Emily SonestedtLund University
- Bo GullbergLund University
- Sophie HellstrandLund University
- George HindyLund University
- Elisabet WirfältLund University
Abstract
Diets high in protein have shown positive effects on short-term weight reduction and glycaemic control. However, the understanding of how dietary macronutrient composition relates to long-term risk of type 2 diabetes is limited. The aim of the present study was to examine intakes of macronutrients, fibre and protein sources in relation to incident type 2 diabetes. In total, 27 140 individuals, aged 45-74 years, from the population-based Malmö Diet and Cancer cohort, were included. Dietary data were collected with a modified diet history method, including registration of cooked meals. During 12 years of follow-up, 1709 incident type 2 diabetes cases were identified. High protein intake was associated with increased risk of type 2 diabetes (hazard ratio (HR) 1.27 for highest compared with lowest quintile; 95 % CI 1.08, 1.49; P for trend = 0.01). When protein consumption increased by 5 % of energy at the expense of carbohydrates (HR 1.20; 95 % CI 1.09, 1.33) or fat (HR 1.21; 95 % CI 1.09, 1.33), increased diabetes risk was observed. Intakes in the highest quintiles of processed meat (HR 1.16; 95 % CI 1.00, 1.36; P for trend = 0.01) and eggs (HR 1.21; 95 % CI 1.04, 1.41; P for trend = 0.02) were associated with increased risk. Intake of fibre-rich bread and cereals was inversely associated with type 2 diabetes (HR 0.84; 95 % CI 0.73, 0.98; P for trend = 0.004). In conclusion, results from the present large population-based prospective study indicate that high protein intake is associated with increased risk of type 2 diabetes. Replacing protein with carbohydrates may be favourable, especially if fibre-rich breads and cereals are chosen as carbohydrate sources.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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