Funded in part by California Walnut Commission
A Mediterranean diet enriched with olive oil is associated with higher serum total osteocalcin levels in elderly men at high cardiovascular risk
Fernández-Real JM, Bulló M, Moreno-Navarrete JM, Ricart W, Ros E, Estruch R, Salas-Salvadó J
The Journal of clinical endocrinology and metabolism · 76 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Industry funded
- Industry group
- California Walnut Commission
- University or hospital
- Universitat Rovira i Virgili
- Government
- Instituto de Salud Carlos III
Based on 3 listed funder(s).
Publication
- Published
- 2012-10-01 · J Clin Endocrinol Metab · vol. 97 · issue 10 · pp. 3792–3798
- Publisher
- Oxford University Press
- Cited
- 91 citations · more than 97% of similar papers · 6.2× the field average
- Impact
- Top 10% most cited in its field
- References
- 26 works
- Access
- Free to read
- Research areas
- Fatty Acid Research and Health · Vitamin K Research Studies · Bone health and osteoporosis research
- Keywords
- Osteocalcin, Mediterranean diet, Endocrinology, Internal medicine, Medicine, Osteoporosis, Resorption, Body mass index, Biology, Alkaline phosphatase, Biochemistry
- MeSH
- humans, nuts, osteoporosis, cardiovascular diseases, collagen type i, plant oils, peptides, osteocalcin, treatment outcome, diet, fat-restricted, risk factors, longitudinal studies, diet, mediterranean, aging, homeostasis, aged, aged, 80 and over, middle aged, male, biomarkers, olive oil
7 authors
From ES
- José Manuel Fernández‐Real · correspondingInstitut d'Investigació Biomèdica de Girona; Hospital Universitari de Girona Doctor Josep Trueta
- Mònica Bulló · correspondingInstituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition
- José María Moreno‐NavarreteHospital Universitari de Girona Doctor Josep Trueta
- Wifredo RicartInstituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Hospital Universitari de Girona Doctor Josep Trueta
- Emilio Peña RosInstituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
- Ramón EstruchInstituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Hospital Clínic de Barcelona
Abstract
Background
The intake of olive oil has been related to the prevention of osteoporosis in experimental and in in vitro models. Very few prospective studies have evaluated the effects of olive oil intake on circulating osteocalcin (OC) in humans.
Objective
The objective of the study was to examine the longitudinal effects of a low-fat control diet (n=34), a Mediterranean diet enriched with nuts (MedDiet+nuts, n=51), or a Mediterranean diet enriched with virgin olive oil (MedDiet+VOO, n=42) on circulating forms of OC and bone formation markers in elderly men at high cardiovascular risk.
Design
Longitudinal associations between baseline and follow-up (2 yr) measurements of total OC, undercarboxylated osteocalcin, C-telopeptide of type I collagen, and procollagen I N-terminal propeptide (P1NP) concentrations were examined in 127 elderly men randomized to three healthy dietary interventions.
Results
Baseline characteristics (age, body mass index, waist circumference, lipid profile, fasting insulin levels, and bone formation and resorption markers) were similar in all intervention groups. The total osteocalcin concentration increased robustly in the MedDiet+VOO group (P=0.007) in parallel to increased P1NP levels (P=0.01) and homeostasis model assessment-β-cell function (P=0.01) but not in subjects on the MedDiet+nuts (P=0.32) or after the control diet (P=0.74). Interestingly, the consumption of olives was associated positively with both baseline total osteocalcin (r=0.23, P=0.02) and the 2-yr osteocalcin concentrations (r=0.21, P=0.04) in the total cohort.
Conclusions
Consumption of a Mediterranean diet enriched with virgin olive oil for 2 years is associated with increased serum osteocalcin and P1NP concentrations, suggesting protective effects on bone.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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