Cruciferous vegetables intake is inversely associated with risk of breast cancer: a meta-analysis
Liu X, Lv K
Breast (Edinburgh, Scotland) · 95 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Not stated
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2012-08-09 · Breast · vol. 22 · issue 3 · pp. 309–313
- Publisher
- Elsevier BV
- Cited
- 160 citations · more than 49% of similar papers · 0.5× the field average
- References
- 41 works
- Access
- Open access (hybrid journal) · CC-BY-NC-ND
- Research areas
- Genomics, phytochemicals, and oxidative stress · Nutritional Studies and Diet · Antioxidant Activity and Oxidative Stress
- Keywords
- Cruciferous vegetables, Medicine, Breast cancer, Meta-analysis, Publication bias, Odds ratio, Cohort study, Cancer, Oncology, Internal medicine, Relative risk, Environmental health, Confidence interval
- MeSH
- humans, brassica, breast neoplasms, diet, confidence intervals, odds ratio, risk factors, female
2 authors
From CN
- Xiaojiao LiuFirst Affiliated Hospital Zhejiang University
- Kezhen Lv · correspondingZhejiang University
Abstract
Purpose
The objective of the study was to examine the associations of cruciferous vegetables intake with risk of breast cancer.
Methods
Studies were identified by searching PubMed databases and screening the references of retrieved articles and reviews. Summary odds ratios (ORs) for the highest versus lowest cruciferous vegetables consumption levels were calculated using fixed or random effects models depending on heterogeneity between studies. Heterogeneity among studies was examined using Q and I(2) statistics. Publication bias was assessed using the Egger's and Begg's tests.
Results
Thirteen epidemiologic studies (11 case-control and 2 cohort studies) were included in the meta-analysis. The combined results from all studies indicated that high cruciferous vegetables intake was significantly associated with reduced breast cancer risk (RR = 0.85, 95% CI = 0.77-0.94).
Conclusion
Findings from this meta-analysis suggest that cruciferous vegetables consumption may reduce the risk of breast cancer. Because of the limited number of studies, further prospective studies are needed to explore the protective effect of cruciferous vegetables on breast cancer.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-ND).
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