Effects of a rapeseed oil-enriched hypoenergetic diet with a high content of α-linolenic acid on body weight and cardiovascular risk profile in patients with the metabolic syndrome
Baxheinrich A, Stratmann B, Lee-Barkey YH, Tschoepe D, Wahrburg U
The British journal of nutrition · 72 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- University or hospital
- Universidade Federal de Ouro Preto
Based on 1 listed funder(s).
Publication
- Published
- 2012-08-16 · Br J Nutr · vol. 108 · issue 4 · pp. 682–691
- Publisher
- Cambridge University Press
- Cited
- 91 citations · more than 93% of similar papers · 3.6× the field average
- Impact
- Top 10% most cited in its field
- References
- 60 works
- Access
- Free to read
- Research areas
- Diet and metabolism studies · Diet, Metabolism, and Disease · Nutritional Studies and Diet
- Keywords
- Rapeseed, Food science, Metabolic syndrome, Linolenic acid, Body weight, Chemistry, Medicine, Obesity, Animal science, Endocrinology, Biochemistry, Fatty acid, Biology, Linoleic acid
- MeSH
- humans, brassica rapa, seeds, cardiovascular diseases, hypertension, weight loss, alpha-linolenic acid, fatty acids, monounsaturated, plant oils, diet, reducing, prevalence, risk factors, feasibility studies, patient compliance, adult, middle aged, patient dropouts, germany, female, male, hyperlipidemias, metabolic syndrome, rapeseed oil
5 authors
From DE
- Andrea Baxheinrich · correspondingFH Münster
- Bernd StratmannHeart and Diabetes Center North Rhine-Westphalia; Ruhr University Bochum
- Young Hee Lee-BarkeyHeart and Diabetes Center North Rhine-Westphalia; Ruhr University Bochum
- Diethelm TschoepeHeart and Diabetes Center North Rhine-Westphalia; Ruhr University Bochum
- Ursel WahrburgFH Münster
Abstract
In therapy of the metabolic syndrome, the optimal dietary approach with regard to its macronutrient composition and metabolically favourable food components, such as the plant-derived n-3 fatty acid α-linolenic acid (ALA), is still a matter of debate. We investigated the effects of a hypoenergetic diet with low energy density (ED) enriched in rapeseed oil, resulting in high MUFA content and an ALA intake of 3.5 g/d on body weight and cardiovascular risk profile in eighty-one patients with the metabolic syndrome in comparison with an olive oil diet rich in MUFA, but with a low ALA content. After a 6-month dietary intervention, body weight was significantly reduced in the rapeseed oil and olive oil groups ( -7.8 v. -6.0 kg; P < 0.05). There were significant decreases in systolic blood pressure, total cholesterol and LDL-cholesterol, and insulin levels in both groups (P < 0.05). For all of these changes, no inter-group differences were observed. After the rapeseed oil diet, diastolic blood pressure declined more than after the olive oil diet (P < 0.05 for time × group interaction). Furthermore, concentrations of serum TAG were significantly reduced after the high ALA intake, but not in the low ALA group (P < 0.05 for time × group interaction). In conclusion, our dietary food pattern with a low ED and high intakes of MUFA and ALA may be a practical approach for long-term dietary treatment in patients with the metabolic syndrome, leading to weight reduction and an improvement in the overall cardiovascular risk profile.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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