Dietary cholesterol increases paraoxonase 1 enzyme activity
Kim DS, Burt AA, Ranchalis JE, Richter RJ, Marshall JK, Nakayama KS, Jarvik ER, Eintracht JF, Rosenthal EA, Furlong CE, Jarvik GP
Journal of lipid research · 34 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cross-sectional study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Independent funding
- Government
- National Heart, Lung, and Blood Institute
- Government
- NHLBI NIH HHS
- Grants
- National Heart, Lung, and Blood Institute (R01 HL067406); National Heart, Lung, and Blood Institute (R01 HL67406)
Based on 2 listed funder(s).
Publication
- Published
- 2012-08-17 · J Lipid Res · vol. 53 · issue 11 · pp. 2450–2458
- Publisher
- Elsevier BV
- Cited
- 45 citations · more than 86% of similar papers · 2.3× the field average
- References
- 100 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Paraoxonase enzyme and polymorphisms · Cynara cardunculus studies · Apelin-related biomedical research
- Keywords
- PON1, Paraoxonase, Cholesterol, Aryldialkylphosphatase, Vitamin, Arylesterase, Internal medicine, Vitamin C, Endocrinology, Medicine, Food science, Biology, Biochemistry, Oxidative stress
- MeSH
- humans, cholesterol, aryldialkylphosphatase, cholesterol, dietary, lipoproteins, hdl, lipoproteins, vldl, apolipoprotein a-i, enzyme activation, genotype, aged, middle aged, female, male
11 authors
From US
- Daniel Seung KimUniversity of Washington
- Amber BurtUniversity of Washington
- Jane RanchalisUniversity of Washington
- Rebecca J. RichterUniversity of Washington
- Julieann K. MarshallUniversity of Washington
- Karen S. NakayamaUniversity of Washington
Abstract
HDL-associated paraoxonase 1 (PON1) activity has been consistently associated with cardiovascular and other diseases. Vitamins C and E intake have previously been positively associated with PON1 in a subset of the Carotid Lesion Epidemiology and Risk (CLEAR) cohort. The goal of this study was to replicate these findings and determine whether other nutrient intake affected PON1 activity. To predict nutrient and mineral intake values, 1,402 subjects completed a standardized food frequency survey of their dietary habits over the past year. Stepwise regression was used to evaluate dietary and covariate effects on PON1 arylesterase activity. Five dietary components, cholesterol (P < 2.0 × 10(-16)), alcohol (P = 8.51 × 10(-8)), vitamin C (P = 7.97 × 10(-5)), iron (P = 0.0026), and folic acid (0.037) were independently predictive of PON1 activity. Dietary cholesterol was positively associated and predicted 5.5% of PON1 activity, second in variance explained. This study presents a novel finding of dietary cholesterol, iron, and folic acid predicting PON1 activity in humans and confirms prior reported associations, including that with vitamin C. Identifying and understanding environmental factors that affect PON1 activity is necessary to understand its role and that of HDL in human disease.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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