Dietary nitrate and nitrite intake and risk of non-Hodgkin lymphoma
Aschebrook-Kilfoy B, Ward MH, Dave BJ, Smith SM, Weisenburger DD, Chiu BC
Leukemia & lymphoma · 10 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Case-control study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Independent funding
- University or hospital
- University of Nebraska Medical Center
- Government
- National Cancer Institute
- Government
- NCI NIH HHS
- Grants
- National Cancer Institute (CA94770); National Cancer Institute (R01CA100555); National Cancer Institute (CA100555)
Based on 3 listed funder(s).
Publication
- Published
- 2012-09-27 · Leuk Lymphoma · vol. 54 · issue 5 · pp. 945–950
- Publisher
- Taylor & Francis
- Cited
- 14 citations · more than 71% of similar papers · 0.6× the field average
- References
- 45 works
- Access
- Open access (repository copy)
- Research areas
- Folate and B Vitamins Research · RNA modifications and cancer · Viral-associated cancers and disorders
- Keywords
- Nitrite, Odds ratio, Quartile, Medicine, Nitrate, Lymphoma, Confidence interval, Internal medicine, Non-Hodgkin's lymphoma, Population, Risk factor, Gastroenterology, Immunology, Environmental health, Biology
- MeSH
- humans, lymphoma, non-hodgkin, nitrates, nitrites, diet, odds ratio, risk, case-control studies
6 authors
From US
- Briseis Aschebrook‐Kilfoy · correspondingChicago Department of Public Health; University of Chicago
- Mary H. WardNational Institutes of Health; National Cancer Institute
- Bhavana J. DavéNebraska Medical Center
- Sonali M. SmithUniversity of Chicago
- Dennis D. WeisenburgerUniversity of Nebraska Medical Center
- Brian C.‐H. ChiuUniversity of Chicago
Abstract
Although established risk factors such as immunodeficiency and viral infections may be responsible for a portion of cases of non-Hodgkin lymphoma (NHL), the vast majority of cases of NHL remain unexplained. The role of dietary nitrate and nitrite in NHL risk is of interest since they are precursors of N-nitroso compounds, and nitrosoureas have been shown to induce B- and T-cell lymphomas in animal studies. However, few studies have evaluated the potential association between consumption of nitrate and nitrite and NHL by subtype or chromosomal translocation status, and the results of these studies have been inconsistent. We estimated the dietary intake of nitrate and nitrite using a food frequency questionnaire in a population-based, case-control study of 348 cases and 470 controls conducted in Nebraska in 1999-2002. A non-significant excess risk of NHL was found among women who reported an intake of nitrite in the highest quartile compared to the lowest quartile (odds ratio [OR] = 1.6; 95% confidence interval [CI]: 0.8-2.9), particularly nitrite from animal sources (OR = 1.9; 95% CI: 1.0-3.4). No significant associations were observed for nitrate or nitrite by NHL subtype. Although there were some increases in risk that support the N-nitroso hypothesis, they were not significant and do not confer strong evidence of an association.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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