Gut microbiome composition is linked to whole grain-induced immunological improvements
Martínez I, Lattimer JM, Hubach KL, Case JA, Yang J, Weber CG, Louk JA, Rose DJ, Kyureghian G, Peterson DA, Haub MD, Walter J
The ISME journal · 430 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Food provided by researchers
Who paid for it
- Funding
- Independent funding
- Government
- U.S. Department of Agriculture
Based on 1 listed funder(s).
Publication
- Published
- 2012-10-04 · ISME J · vol. 7 · issue 2 · pp. 269–280
- Publisher
- Springer Nature
- Cited
- 633 citations · more than 99% of similar papers · 8.9× the field average
- Impact
- Top 10% most cited in its field
- References
- 67 works
- Access
- Free to read
- Research areas
- Gut microbiota and health · Food composition and properties · Probiotics and Fermented Foods
- Keywords
- Roseburia, Biology, Firmicutes, Postprandial, Gut flora, Eubacterium, Prebiotic, Bacteroidetes, Microbiome, Lachnospiraceae, Feces, Bifidobacterium, Physiology, Microbiology, Zoology, Food science, Lactobacillus, Insulin, Immunology, Endocrinology, Bacteria, Fermentation, Bioinformatics
- MeSH
- gastrointestinal tract, feces, humans, bacteroidetes, bifidobacterium, eubacterium, hordeum, inflammation, insulin, blood glucose, interleukin-6, diet, cross-over studies, biodiversity, adult, female, male, young adult, metagenome, biomarkers, oryza, edible grain
12 authors
From US
- Inés MartínezUniversity of Nebraska–Lincoln
- James M LattimerKansas State University
- Kelcie L. HubachKansas State University
- Jennifer A CaseKansas State University
- Junyi YangUniversity of Nebraska–Lincoln
- C. WeberKansas State University
Abstract
The involvement of the gut microbiota in metabolic disorders, and the ability of whole grains to affect both host metabolism and gut microbial ecology, suggest that some benefits of whole grains are mediated through their effects on the gut microbiome. Nutritional studies that assess the effect of whole grains on both the gut microbiome and human physiology are needed. We conducted a randomized cross-over trial with four-week treatments in which 28 healthy humans consumed a daily dose of 60 g of whole-grain barley (WGB), brown rice (BR), or an equal mixture of the two (BR+WGB), and characterized their impact on fecal microbial ecology and blood markers of inflammation, glucose and lipid metabolism. All treatments increased microbial diversity, the Firmicutes/Bacteroidetes ratio, and the abundance of the genus Blautia in fecal samples. The inclusion of WGB enriched the genera Roseburia, Bifidobacterium and Dialister, and the species Eubacterium rectale, Roseburia faecis and Roseburia intestinalis. Whole grains, and especially the BR+WGB treatment, reduced plasma interleukin-6 (IL-6) and peak postprandial glucose. Shifts in the abundance of Eubacterium rectale were associated with changes in the glucose and insulin postprandial response. Interestingly, subjects with greater improvements in IL-6 levels harbored significantly higher proportions of Dialister and lower abundance of Coriobacteriaceae. In conclusion, this study revealed that a short-term intake of whole grains induced compositional alterations of the gut microbiota that coincided with improvements in host physiological measures related to metabolic dysfunctions in humans.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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