Effects of short-term dietary nitrate supplementation on blood pressure, O2 uptake kinetics, and muscle and cognitive function in older adults
Kelly J, Fulford J, Vanhatalo A, Blackwell JR, French O, Bailey SJ, Gilchrist M, Winyard PG, Jones AM
American journal of physiology. Regulatory, integrative and comparative physiology · 175 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2012-11-23 · Am J Physiol Regul Integr Comp Physiol · vol. 304 · issue 2 · pp. R73–R83
- Publisher
- American Physiological Society
- Cited
- 230 citations · more than 100% of similar papers · 48.0× the field average
- Impact
- Top 10% most cited in its field
- References
- 87 works
- Access
- Paywalled
- Research areas
- Cardiovascular and exercise physiology · Nitric Oxide and Endothelin Effects · Heart Rate Variability and Autonomic Control
- Keywords
- Blood pressure, Crossover study, Nitrite, Nitrate, Dietary Nitrate, Placebo, Treadmill, Internal medicine, Endocrinology, Chemistry, Medicine, Animal science, Biology
- MeSH
- muscle, skeletal, brain, humans, beta vulgaris, plant roots, nitrates, phosphocreatine, exercise test, walking, diet, cross-over studies, double-blind method, cognition, neuropsychological tests, age factors, oxygen consumption, aging, blood pressure, exercise tolerance, kinetics, beverages, dietary supplements, aged, middle aged, england, female, male
9 authors
From GB
- JAMES A. KELLY
- Jonathan FulfordNational Institute for Health and Care Research
- Anni Vanhatalo
- Jamie R. Blackwell
- Olivia French
- Stephen J. Bailey
Abstract
Dietary nitrate (NO(3)(-)) supplementation has been shown to reduce resting blood pressure and alter the physiological response to exercise in young adults. We investigated whether these effects might also be evident in older adults. In a double-blind, randomized, crossover study, 12 healthy, older (60-70 yr) adults supplemented their diet for 3 days with either nitrate-rich concentrated beetroot juice (BR; 2 × 70 ml/day, ∼9.6 mmol/day NO(3)(-)) or a nitrate-depleted beetroot juice placebo (PL; 2 × 70 ml/day, ∼0.01 mmol/day NO(3)(-)). Before and after the intervention periods, resting blood pressure and plasma [nitrite] were measured, and subjects completed a battery of physiological and cognitive tests. Nitrate supplementation significantly increased plasma [nitrite] and reduced resting systolic (BR: 115 ± 9 vs. PL: 120 ± 6 mmHg; P < 0.05) and diastolic (BR: 70 ± 5 vs. PL: 73 ± 5 mmHg; P < 0.05) blood pressure. Nitrate supplementation resulted in a speeding of the Vo(2) mean response time (BR: 25 ± 7 vs. PL: 28 ± 7 s; P < 0.05) in the transition from standing rest to treadmill walking, although in contrast to our hypothesis, the O(2) cost of exercise remained unchanged. Functional capacity (6-min walk test), the muscle metabolic response to low-intensity exercise, brain metabolite concentrations, and cognitive function were also not altered. Dietary nitrate supplementation reduced resting blood pressure and improved Vo(2) kinetics during treadmill walking in healthy older adults but did not improve walking or cognitive performance. These results may have implications for the enhancement of cardiovascular health in older age.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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