Egg consumption and risk of coronary heart disease and stroke: dose-response meta-analysis of prospective cohort studies
Rong Y, Chen L, Zhu T, Song Y, Yu M, Shan Z, Sands A, Hu FB, Liu L
BMJ (Clinical research ed.) · 243 citations
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- Government
- National Natural Science Foundation of China
- Government
- National Key Research and Development Program of China
- Government
- National Institute of Diabetes and Digestive and Kidney Diseases
- Government
- NIDDK NIH HHS
- Grants
- National Institute of Diabetes and Digestive and Kidney Diseases (T-32 DK 007703); National Natural Science Foundation of China (NSFC 81072291); National Key Research and Development Program of China (2009CB118803)
Based on 4 listed funder(s).
Publication
- Published
- 2013-01-07 · BMJ · vol. 346 · issue jan07 2 · p. e8539
- Cited
- 373 citations · more than 98% of similar papers · 6.9× the field average
- Impact
- Top 10% most cited in its field
- References
- 82 works
- Access
- Open access (hybrid journal) · CC-BY-NC
- Research areas
- Nutritional Studies and Diet · Antioxidant Activity and Oxidative Stress · Phytoestrogen effects and research
- Keywords
- Medicine, Stroke (engine), Relative risk, Prospective cohort study, Confidence interval, Internal medicine, Cohort study, Meta-analysis, Cohort, Subgroup analysis, Myocardial infarction, Coronary artery disease, Cardiology
- MeSH
- humans, coronary disease, diabetes mellitus, cholesterol, dietary, risk assessment, prospective studies, eggs, practice guidelines as topic, stroke
9 authors
From CN, US
- Y. RongTongji University; Huazhong University of Science and Technology
- Lijun ChenTongji University; Huazhong University of Science and Technology
- Tao ZhuTongji University; Huazhong University of Science and Technology
- Yadong SongTongji University; Huazhong University of Science and Technology
- Yu MaTongji University; Huazhong University of Science and Technology
- Zhilei ShanTongji University; Huazhong University of Science and Technology
Abstract
Objective
To investigate and quantify the potential dose-response association between egg consumption and risk of coronary heart disease and stroke.
Design
Dose-response meta-analysis of prospective cohort studies.
Data sources
PubMed and Embase prior to June 2012 and references of relevant original papers and review articles.
Eligibility criteria for selecting studies
Prospective cohort studies with relative risks and 95% confidence intervals of coronary heart disease or stroke for three or more categories of egg consumption.
Results
Eight articles with 17 reports (nine for coronary heart disease, eight for stroke) were eligible for inclusion in the meta-analysis (3,081,269 person years and 5847 incident cases for coronary heart disease, and 4,148,095 person years and 7579 incident cases for stroke). No evidence of a curve linear association was seen between egg consumption and risk of coronary heart disease or stroke (P=0.67 and P=0.27 for non-linearity, respectively). The summary relative risk of coronary heart disease for an increase of one egg consumed per day was 0.99 (95% confidence interval 0.85 to 1.15; P=0.88 for linear trend) without heterogeneity among studies (P=0.97, I(2)=0%). For stroke, the combined relative risk for an increase of one egg consumed per day was 0.91 (0.81 to 1.02; P=0.10 for linear trend) without heterogeneity among studies (P=0.46, I(2)=0%). In a subgroup analysis of diabetic populations, the relative risk of coronary heart disease comparing the highest with the lowest egg consumption was 1.54 (1.14 to 2.09; P=0.01). In addition, people with higher egg consumption had a 25% (0.57 to 0.99; P=0.04) lower risk of developing hemorrhagic stroke.
Conclusions
Higher consumption of eggs (up to one egg per day) is not associated with increased risk of coronary heart disease or stroke. The increased risk of coronary heart disease among diabetic patients and reduced risk of hemorrhagic stroke associated with higher egg consumption in subgroup analyses warrant further studies.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC).
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