Funded in part by Egg Nutrition Center
Egg consumption modulates HDL lipid composition and increases the cholesterol-accepting capacity of serum in metabolic syndrome
Andersen CJ, Blesso CN, Lee J, Barona J, Shah D, Thomas MJ, Fernandez ML
Lipids · 66 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Industry funded
- Industry group
- Egg Nutrition Center
- Government
- National Institute of Food and Agriculture
- Government
- National Cancer Institute
- Government
- National Center for Research Resources
- Government
- NCI NIH HHS
- Government
- NCRR NIH HHS
- Grants
- National Cancer Institute (5-P30-CA12197); National Cancer Institute (P30CA012197); National Center for Research Resources (1S10RR027940MS); National Center for Research Resources (S10 RR027940)
Based on 6 listed funder(s).
Publication
- Published
- 2013-03-14 · Lipids · vol. 48 · issue 6 · pp. 557–567
- Publisher
- Wiley
- Cited
- 93 citations · more than 95% of similar papers · 4.4× the field average
- Impact
- Top 10% most cited in its field
- References
- 66 works
- Access
- Open access (repository copy)
- Research areas
- Diet, Metabolism, and Disease · Diabetes, Cardiovascular Risks, and Lipoproteins · Liver Disease Diagnosis and Treatment
- Keywords
- Yolk, Cholesterol, Internal medicine, Phospholipid, Sphingomyelin, Phosphatidylethanolamine, Endocrinology, Composition (language), Lipidology, Cholesteryl ester, Biology, Lipoprotein, Chemistry, Biochemistry, Food science, Phosphatidylcholine, Medicine
- MeSH
- egg yolk, humans, body weight, lipids, lipoproteins, hdl, phospholipids, eggs, adult, aged, middle aged, female, male, lipid metabolism, diet, carbohydrate-restricted, cholesterol, hdl, metabolic syndrome
7 authors
From US, CO
- Catherine J. AndersenUniversity of Connecticut
- Christopher N. BlessoUniversity of Connecticut; Wake Forest University
- Ji‐Young LeeUniversity of Connecticut
- Jacqueline BaronaUniversity of Connecticut; Universidad de Antioquia
- Dharika ShahWake Forest University
- Michael J. ThomasWake Forest University
Abstract
We recently demonstrated that daily whole egg consumption during moderate carbohydrate restriction leads to greater increases in plasma HDL-cholesterol (HDL-C) and improvements in HDL profiles in metabolic syndrome (MetS) when compared to intake of a yolk-free egg substitute. We further investigated the effects of this intervention on HDL composition and function, hypothesizing that the phospholipid species present in egg yolk modulate HDL lipid composition to increase the cholesterol-accepting capacity of subject serum. Men and women classified with MetS were randomly assigned to consume either three whole eggs (EGG, n = 20) per day or the equivalent amount of egg substitute (SUB, n = 17) throughout a 12-week moderate carbohydrate-restricted (25-30 % of energy) diet. Relative to other HDL lipids, HDL-cholesteryl ester content increased in all subjects, with greater increases in the SUB group. Further, HDL-triacylglycerol content was reduced in EGG group subjects with normal baseline plasma HDL-C, resulting in increases in HDL-CE/TAG ratios in both groups. Phospholipid analysis by mass spectrometry revealed that HDL became enriched in phosphatidylethanolamine in the EGG group, and that EGG group HDL better reflected sphingomyelin species present in the whole egg product at week 12 compared to baseline. Further, macrophage cholesterol efflux to EGG subject serum increased from baseline to week 12, whereas no changes were observed in the SUB group. Together, these findings suggest that daily egg consumption promotes favorable shifts in HDL lipid composition and function beyond increasing plasma HDL-C in MetS.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.