Low-level laser therapy can produce increased aggressiveness of dysplastic and oral cancer cell lines by modulation of Akt/mTOR signaling pathway
Sperandio FF, Giudice FS, Corrêa L, Pinto DS, Hamblin MR, de Sousa SC
Journal of biophotonics · 71 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- In vitro/mechanistic study (classified by our AI screen)
- Studied in
- Cells or lab samples
- Main outcome
- Mechanisms only
Who paid for it
- Funding
- Independent funding
- Government
- National Institute of Allergy and Infectious Diseases
- Government
- NIAID NIH HHS
- Grants
- National Institute of Allergy and Infectious Diseases (R01 AI050875)
Based on 2 listed funder(s).
Publication
- Published
- 2013-04-02 · J Biophotonics · vol. 6 · issue 10 · pp. 839–847
- Publisher
- Wiley
- Cited
- 109 citations · more than 96% of similar papers · 5.3× the field average
- Impact
- Top 10% most cited in its field
- References
- 55 works
- Access
- Open access (repository copy)
- Research areas
- Laser Applications in Dentistry and Medicine · Oral health in cancer treatment
- Keywords
- Mucositis, Protein kinase B, Low level laser therapy, PI3K/AKT/mTOR pathway, Cancer, Cancer research, Medicine, Cyclin D1, Cancer cell, Apoptosis, Chemistry, Internal medicine, Laser therapy, Cell cycle, Radiation therapy, Laser, Biochemistry
- MeSH
- cell line, tumor, humans, mouth neoplasms, signal transduction, apoptosis, cell proliferation, cell survival, gene expression regulation, enzymologic, proto-oncogene proteins c-akt, tor serine-threonine kinases, low-level light therapy, proto-oncogene mas
6 authors
From US, BR
- Felipe Fornias Sperandio · correspondingHarvard University; Universidade de São Paulo; Massachusetts General Hospital
- Fernanda Salgueiredo GiudiceUniversidade de São Paulo; Universidade Cidade de São Paulo
- Luciana Roberta do Vale CorrêaUniversidade de São Paulo; Universidade Cidade de São Paulo
- Décio dos Santos Pinto JúniorUniversidade de São Paulo; Universidade Cidade de São Paulo
- Michael R. HamblinHarvard University; Massachusetts General Hospital; Harvard–MIT Division of Health Sciences and Technology
- Suzana Cantanhede Orsini Machado de SousaUniversidade de São Paulo; Universidade Cidade de São Paulo
Abstract
Low-level laser therapy (LLLT) is a non-thermal phototherapy used in several medical applications, including wound healing, reduction of pain and amelioration of oral mucositis. Nevertheless, the effects of LLLT upon cancer or dysplastic cells have been so far poorly studied. Head and neck cancer patients receiving LLLT for oral mucositis, for example, might have remaining tumor cells that could be stimulated by LLLT. This study demonstrated that LLLT (GaAlAs--660 nm or 780 nm, 40 mW, 2.05, 3.07 or 6.15 J/cm²) can modify oral dysplastic cells (DOK) and oral cancer cells (SCC9 and SCC25) growth by modulating the Akt/mTOR/CyclinD1 signaling pathway; LLLT significantly modified the expression of proteins related to progression and invasion in all the cell lines, and could aggravate oral cancer cellular behavior, increasing the expression of pAkt, pS6 and Cyclin D1 proteins and producing an aggressive Hsp90 isoform. Apoptosis was detected for SCC25 and was related to pAkt levels.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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