Funded in part by Danone
Circadian variation and responsiveness of hydration biomarkers to changes in daily water intake
Perrier E, Demazières A, Girard N, Pross N, Osbild D, Metzger D, Guelinckx I, Klein A
European journal of applied physiology · 113 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Industry funded
- Company
- Danone
Based on 1 listed funder(s).
Publication
- Published
- 2013-04-21 · Eur J Appl Physiol · vol. 113 · issue 8 · pp. 2143–2151
- Publisher
- Springer Science+Business Media
- Cited
- 141 citations · more than 97% of similar papers · 5.8× the field average
- Impact
- Top 10% most cited in its field
- References
- 27 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Thermoregulation and physiological responses · Climate Change and Health Impacts · Dietary Effects on Health
- Keywords
- Circadian rhythm, Human physiology, Variation (astronomy), Sports medicine, Chronobiology, Physiology, Medicine, Internal medicine, Biology, Endocrinology, Physical therapy
- MeSH
- saliva, plasma, urine, humans, dehydration, case-control studies, prospective studies, cross-over studies, water-electrolyte balance, circadian rhythm, drinking, osmolar concentration, adult, female, male, biomarkers
8 authors
From FR
- Erica T. Perrier · correspondingDanone (France)
- A. DemazièresCentre hospitalier de Rouffach
- Nicolas GirardCentre hospitalier de Rouffach
- Nathalie ProssCentre hospitalier de Rouffach
- Dominique OsbildCentre hospitalier de Rouffach
- DEBORAH A. METZGERCentre hospitalier de Rouffach
Abstract
Biomarkers of hydration change in response to acute dehydration; however, their responsiveness to changes in fluid intake volume, without exercise or heat exposure, has not been adequately described. Moreover, patterns of circadian variation in hydration biomarkers have not been established. The study aims were to (1) assess the response of hydration biomarkers to changes in daily water intake; and (2) evaluate circadian variation in urinary and salivary biomarkers. Fifty-two adults (24.8 ± 3.1 years; 22.3 ± 1.6 kg/m(2); 79 % female), grouped based on habitual fluid intake (low drinkers, n = 30, 2.0 L/day), completed a 5-day inpatient crossover trial. On days 1 and 2, low drinkers received 1.0 L/day of water while high drinkers received 2.5 L/day. On days 3 through 5, intake was reversed between groups. Plasma and saliva osmolality were assessed daily at predetermined times, and all urine produced over 24 h was collected in timed intervals. ANOVA with intake (1.0 vs. 2.5 L/day), day, and time revealed that (1) urine concentration (osmolality, specific gravity, color) and volume, but not plasma nor saliva osmolality, responded to changes in water intake; (2) urinary hydration biomarkers and saliva osmolality vary as a function of the time of day; and (3) urine osmolality measured in samples collected during the afternoon most closely reflects the corresponding 24 h value. Overall, urinary hydration biomarkers are responsive to changes in water intake, and stabilize within 24 h of modifying intake volume. Moreover, short afternoon urine collections may be able to replace 24 h collections for more convenience in hydration assessment.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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