Cruciferous vegetable consumption and gastric cancer risk: a meta-analysis of epidemiological studies
Wu QJ, Yang Y, Wang J, Han LH, Xiang YB
Cancer science · 67 citations
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- Government
- National Mega Project on Major Infectious Disease Prevention
Based on 1 listed funder(s).
Publication
- Published
- 2013-05-16 · Cancer Sci · vol. 104 · issue 8 · pp. 1067–1073
- Publisher
- Wiley
- Cited
- 108 citations · more than 98% of similar papers · 9.0× the field average
- Impact
- Top 10% most cited in its field
- References
- 61 works
- Access
- Free to read
- Research areas
- Helicobacter pylori-related gastroenterology studies · Genomics, phytochemicals, and oxidative stress · Gastric Cancer Management and Outcomes
- Keywords
- Medicine, Meta-analysis, Cruciferous vegetables, Cancer, Publication bias, Confidence interval, Relative risk, Study heterogeneity, Internal medicine, Epidemiology, Prospective cohort study, Stomach cancer, Gastroenterology, Oncology
- MeSH
- humans, brassica, vegetables, stomach neoplasms, diet, risk, epidemiologic studies, case-control studies, prospective studies, female, male
5 authors
From CN
- Qi‐Jun WuRenji Hospital; Shanghai Cancer Institute; State Key Laboratory of Oncogene and Related Genes
- Yang YangRenji Hospital; Shanghai Cancer Institute; State Key Laboratory of Oncogene and Related Genes
- Jing WangRenji Hospital; Shanghai Cancer Institute; State Key Laboratory of Oncogene and Related Genes
- Li‐Hua HanRenji Hospital; Shanghai Cancer Institute; State Key Laboratory of Oncogene and Related Genes
- Yong‐Bing Xiang · correspondingRenji Hospital; Shanghai Cancer Institute; State Key Laboratory of Oncogene and Related Genes
Abstract
The relationship between consumption of cruciferous vegetables (CV) and risk of gastric cancer has been investigated by many studies, but remains controversial. We carried out a meta-analysis to summarize available evidence from epidemiological studies on this point. Relevant published reports of CV intake and gastric cancer were identified using MEDLINE (PubMed), EMBASE, and Web of Science databases through to the end of September 2012. We pooled the relative risk from individual studies using a fixed- or random-effects model and carried out heterogeneity and publication bias analyses. Sixteen case-control and six prospective studies were included in our analysis. When all studies were pooled, we yielded a significantly inverse association between CV (relative risk = 0.81; 95% confidence interval, 0.75-0.88) intake and gastric cancer risk, with little heterogeneity (Q = 27.27, P = 0.292, I(2) = 12.0%). Specific analysis for cabbage intake yielded similar result. When separately analyzed, case-control studies of CV intake yielded significant results and the results of prospective studies showed borderline statistical significance. Moreover, significant results were consistent for high-quality studies, for North American, European, and Asian studies, for studies on males, and for studies on non-cardia gastric cancer. Findings from this meta-analysis provide evidence that high intake of CV was inversely associated with the risk of gastric cancer and non-cardia gastric cancer in humans. Further studies on other specific CV, food preparation methods, and stratified results by anatomic cancer site and histological type should be extended in the future.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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