Funded in part by Biogen, Teva Pharmaceutical Industries
Virgin olive oil supplementation and long-term cognition: the PREDIMED-NAVARRA randomized, trial
Martínez-Lapiscina EH, Clavero P, Toledo E, San Julián B, Sanchez-Tainta A, Corella D, Lamuela-Raventós RM, Martínez JA, Martínez-Gonzalez MÁ
The journal of nutrition, health & aging · 192 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Industry funded
- Company
- Biogen
- Company
- Teva Pharmaceutical Industries
- Government
- Instituto de Salud Carlos III
- Authors
- At least one author declares a financial tie to industry
Based on 3 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2013-03-17 · J Nutr Health Aging · vol. 17 · issue 6 · pp. 544–552
- Publisher
- Springer Science+Business Media
- Cited
- 267 citations · more than 100% of similar papers · 21.0× the field average
- Impact
- Top 10% most cited in its field
- References
- 83 works
- Access
- Open access (hybrid journal) · CC-BY-NC-ND
- Research areas
- Nutritional Studies and Diet · Nuts composition and effects · Diet and metabolism studies
- Keywords
- Mediterranean diet, Medicine, Randomized controlled trial, Cognition, Cognitive decline, Body mass index, Dementia, Gerontology, Type 2 diabetes, Physical therapy, Diabetes mellitus, Internal medicine, Psychiatry, Endocrinology, Disease
- MeSH
- humans, nuts, dementia, plant oils, body mass index, treatment outcome, diet, fat-restricted, nutrition assessment, multivariate analysis, logistic models, follow-up studies, feeding behavior, patient compliance, motor activity, cognition, diet, mediterranean, energy intake, dietary supplements, aged, aged, 80 and over, middle aged, female, male, olive oil, surveys and questionnaires, cognitive dysfunction
9 authors
From ES
- Elena Hernandez Martinez-Lapiscina · correspondingClinica Universidad de Navarra; Universidad de Navarra
- Pedro ClaveroComplejo Hospitalario de Navarra
- Estefanía ToledoInstituto de Salud Carlos III; Universidad de Navarra
- Bao-Quyn JulianUniversidad de Navarra
- Ana Sánchez‐TaintaUniversidad de Navarra
- Dolores CorellaUniversitat de València; Instituto de Salud Carlos III
Abstract
Objective
To assess the effect on cognition of a controlled intervention testing Mediterranean diets (MedDiet).
Design
Randomized trial after 6.5 years of nutritional intervention.
Setting
Eight primary care centers affiliated to the University of Navarra.
Participants
A random subsample of 285 participants (95 randomly allocated to each of 3 groups) of the PREDIMED-NAVARRA trial. All of them were at high vascular risk (44.8% men, 74.1±5.7 years at cognitive evaluation).
Interventions
Nutritional intervention comparing two MedDiets (supplemented with extra-virgin olive oil [EVOO] or mixed nuts) versus a low-fat control diet. Participants received intensive education to increase adherence to the intended intervention. Participants allocated to the MedDiet groups received EVOO (1 l/week) or 30 g/day of mixed nuts. Dietary habits were evaluated using a validated 137-item food frequency questionnaire (FFQ). Additionally, adherence to MedDiet was appraised using a 14-item questionnaire both at baseline and yearly thereafter.
Measurements
Cognitive performance as a main outcome and cognitive status (normal, mild cognitive impairment [MCI] or dementia) as a secondary outcome were evaluated by two neurologists blinded to group assignment after 6.5 years of nutritional intervention.
Results
Better post-trial cognitive performance versus control in all cognitive domains and significantly better performance across fluency and memory tasks were observed for participants allocated to the MedDiet+EVOO group. After adjustment for sex, age, education, apolipoprotein E genotype, family history of cognitive impairment/dementia, smoking, physical activity, body mass index, hypertension, dyslipidaemia, diabetes, alcohol and total energy intake, this group also showed lower MCI (OR=0.34 95% CI: 0.12-0.97) compared with control group. Participants assigned to MedDiet+Nuts group did not differ from controls.
Conclusion
A long-term intervention with an EVOO-rich MedDiet resulted in a better cognitive function in comparison with a control diet. However, non-significant differences were found for most cognitive domains. Participants allocated to an EVOO-rich MedDiet had less MCI than controls.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-ND).
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