Postdiagnosis cruciferous vegetable consumption and breast cancer outcomes: a report from the After Breast Cancer Pooling Project
Nechuta S, Caan BJ, Chen WY, Kwan ML, Lu W, Cai H, Poole EM, Flatt SW, Zheng W, Zheng W, Pierce JP, Shu XO
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 20 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Independent funding
- Government
- National Cancer Institute
- Government
- National Institute of Environmental Health Sciences
- Government
- NIEHS NIH HHS
- Government
- NCI NIH HHS
- Grants
- National Institute of Environmental Health Sciences (K12ES015855); National Cancer Institute (R01CA129059); National Cancer Institute (P01 CA087969); National Cancer Institute (T32CA009001); National Cancer Institute (R01 CA 118229); National Cancer Institute (3R01 CA118229-03S1); National Institute of Environmental Health Sciences (5K12ES015855); National Cancer Institute ([P01 CA87969)
Based on 4 listed funder(s).
Publication
- Published
- 2013-06-14 · Cancer Epidemiol Biomarkers Prev · vol. 22 · issue 8 · pp. 1451–1456
- Publisher
- American Association for Cancer Research
- Cited
- 25 citations · more than 75% of similar papers · 1.0× the field average
- References
- 27 works
- Access
- Open access (repository copy)
- Research areas
- Genomics, phytochemicals, and oxidative stress · Cancer Risks and Factors · Family Support in Illness
- Keywords
- Breast cancer, Medicine, Cruciferous vegetables, Pooling, Oncology, Cancer, Gynecology, Internal medicine, Environmental health
- MeSH
- humans, brassicaceae, vegetables, breast neoplasms, isothiocyanates, neoplasm staging, treatment outcome, diet, cohort studies, prospective studies, feeding behavior, middle aged, united states, china, female
11 authors
From US, CN
- Sarah Nechuta · correspondingBrigham and Women's Hospital; Kaiser Permanente; Harvard University; Dana-Farber Cancer Institute; Shanghai Municipal Center For Disease Control Prevention
- Bette Jane CaanBrigham and Women's Hospital; Kaiser Permanente; Harvard University; Dana-Farber Cancer Institute; Shanghai Municipal Center For Disease Control Prevention
- Wendy Y. ChenBrigham and Women's Hospital; Kaiser Permanente; Dana-Farber Cancer Institute; Shanghai Municipal Center For Disease Control Prevention
- Marilyn L. KwanBrigham and Women's Hospital; Kaiser Permanente; Harvard University; Dana-Farber Cancer Institute; Shanghai Municipal Center For Disease Control Prevention
- Wei LuBrigham and Women's Hospital; Kaiser Permanente; Harvard University; Dana-Farber Cancer Institute; Shanghai Municipal Center For Disease Control Prevention
- Hui CaiBrigham and Women's Hospital; Kaiser Permanente; Harvard University; Dana-Farber Cancer Institute; Shanghai Municipal Center For Disease Control Prevention
Abstract
Cruciferous vegetables are a major source of glucosinolate-derived bioactive compounds such as isothiocyanates, which have been shown in animal and in vitro studies to inhibit cancer growth and progression. Few studies have investigated cruciferous vegetable intake after diagnosis and breast cancer outcomes. Using data from the After Breast Cancer Pooling Project, which includes prospective data from U.S. and Chinese breast cancer survivors, we evaluated the association of cruciferous vegetables with breast cancer outcomes. Analyses included 11,390 women diagnosed with stage I-III invasive breast cancer (1990-2006) from four cohorts. Cruciferous vegetable intake (g/day) was assessed using food frequency questionnaires (mean of 22 months postdiagnosis). Study heterogeneity was evaluated by the Q statistic; hazard ratios (HRs) and 95% confidence intervals (CI) were estimated using delayed-entry Cox regression models stratified by study. After a median follow-up of 9.0 years, 1,725 deaths and 1,421 recurrences were documented. In pooled analyses using study-specific quartiles, cruciferous vegetable intake was not associated with breast cancer outcomes, adjusting for known clinical prognostic factors and selected lifestyle factors. HRs (95% CIs) by increasing quartiles (reference = lowest quartile) were 1.08 (0.93-1.25), 1.01 (0.87-1.18), and 1.10 (0.95-1.28) for recurrence (P(trend) = 0.34) and 1.01 (0.88-1.15), 0.97 (0.84-1.11), and 0.99 (0.86-1.13) for total mortality (P(trend) = 0.84). No associations were observed for subgroups defined by estrogen receptor status, stage, or tamoxifen therapy. Cruciferous vegetable intake at approximately two years after diagnosis was not associated with recurrence or mortality. Our results do not support an association between postdiagnosis cruciferous vegetable intake and breast cancer outcomes.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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