Egg consumption and insulin metabolism in the Insulin Resistance Atherosclerosis Study (IRAS)
Lee CT, Liese AD, Lorenzo C, Wagenknecht LE, Haffner SM, Rewers MJ, Hanley AJ
Public health nutrition · 7 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cross-sectional study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Independent funding
- University or hospital
- University of Toronto
- Government
- National Institutes of Health
- Government
- National Heart, Lung, and Blood Institute
- Government
- National Institute of Diabetes and Digestive and Kidney Diseases
- Government
- NIDDK NIH HHS
- Government
- NHLBI NIH HHS
- Grants
- National Heart, Lung, and Blood Institute (U01 HL 47892); National Heart, Lung, and Blood Institute (HL-47902); National Heart, Lung, and Blood Institute (R01-58329); National Heart, Lung, and Blood Institute (U01 HL 47902); National Institutes of Health (M01-RR-43); National Heart, Lung, and Blood Institute (HL 47892); National Heart, Lung, and Blood Institute (U01 HL047892); National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK029867); National Heart, Lung, and Blood Institute (DK-29867); National Heart, Lung, and Blood Institute (U01 HL047902); National Institutes of Health (DK29867)
Based on 6 listed funder(s).
Publication
- Published
- 2013-06-19 · Public Health Nutr · vol. 17 · issue 7 · pp. 1595–1602
- Publisher
- Cambridge University Press
- Cited
- 11 citations · more than 68% of similar papers · 0.3× the field average
- References
- 24 works
- Access
- Free to read
- Research areas
- Nutritional Studies and Diet · Obesity, Physical Activity, Diet · Consumer Attitudes and Food Labeling
- Keywords
- Insulin resistance, Insulin, Internal medicine, Endocrinology, Medicine, Insulin sensitivity, Diabetes mellitus, Cholesterol
- MeSH
- humans, insulin resistance, insulin, blood glucose, cholesterol, dietary, glucose tolerance test, body mass index, diet, fasting, cross-sectional studies, feeding behavior, eggs, middle aged, female, male
7 authors
From CA, US
- Chee-Tin Christine LeeUniversity of Toronto
- Angela D. LieseUniversity of South Carolina
- Carlos LorenzoThe University of Texas at San Antonio Health Science Center
- Lynne E. WagenknechtWake Forest University
- Steven M. HaffnerBaylor College of Medicine
- Marian RewersUniversity of Colorado Denver
Abstract
Objective
To examine the association between egg consumption and measures of insulin sensitivity (SI), acute insulin response (AIR) and metabolic clearance rate of insulin (MCRI).
Design
Cross-sectional analysis.
Settings
Egg consumption, categorized as <1/week, 1 to <3/week, 3 to <5/week and ≥5/week, was measured using a validated FFQ. SI, AIR and MCRI were determined from frequently sampled intravenous glucose tolerance tests.
Subjects
Non-diabetic participants (n 949) in the Insulin Resistance Atherosclerosis Study (IRAS).
Results
Egg consumption was inversely associated with SI and MCRI, and positively associated with fasting insulin in regression models adjusted for demographic, socio-economic, lifestyle and dietary factors (β = -0·22, 95 % CI -0·38, -0·045, P = 0·05 for SI; β = -0·20, 95 % CI -0·34, -0·055, P = 0·005 for MCRI; β = 0·35, 95 % CI 0·15, 0·54, P = 0·002 for fasting insulin; all P values for linear trend). These associations remained significant after additionally adjusting for energy intake or dietary saturated fat, although dietary cholesterol and BMI attenuated these associations to non-significance. Egg consumption was not associated with AIR.
Conclusions
Dietary cholesterol and BMI appear to mediate the inverse association of egg consumption with insulin sensitivity and clearance. Alternatively, egg consumption may be clustered with other dietary behaviours which increase BMI, hence negatively impacting on insulin sensitivity and clearance.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.