Cruciferous vegetables consumption and risk of renal cell carcinoma: a meta-analysis
Liu B, Mao Q, Wang X, Zhou F, Luo J, Wang C, Lin Y, Zheng X, Xie L
Nutrition and cancer · 32 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Not stated
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2013-07-01 · Nutr Cancer · vol. 65 · issue 5 · pp. 668–676
- Publisher
- Routledge
- Cited
- 47 citations · more than 34% of similar papers · 0.3× the field average
- References
- 65 works
- Access
- Paywalled
- Research areas
- Genomics, phytochemicals, and oxidative stress · Glutathione Transferases and Polymorphisms
- Keywords
- Renal cell carcinoma, Cruciferous vegetables, Medicine, Confidence interval, Cohort study, Relative risk, Meta-analysis, Internal medicine, Cohort, Prospective cohort study, Carcinoma, Kidney cancer, Publication bias, Lower risk, Case-control study, Oncology, Cancer
- MeSH
- humans, brassicaceae, vegetables, carcinoma, renal cell, diet, risk factors
9 authors
From CN
- Ben LiuFirst Affiliated Hospital Zhejiang University; Zhejiang University
- Qiqi MaoFirst Affiliated Hospital Zhejiang University; Zhejiang University
- Xiao WangFirst Affiliated Hospital Zhejiang University; Zhejiang University
- Feng ZhouFirst Affiliated Hospital Zhejiang University; Zhejiang University
- Jindan LuoFirst Affiliated Hospital Zhejiang University; Zhejiang University
- Chaojun WangFirst Affiliated Hospital Zhejiang University; Zhejiang University
Abstract
Previous cohort and case-control studies on the association between cruciferous vegetables consumption and risk of renal cell carcinoma have illustrated conflicting results so far. To demonstrate the potential association between them, a meta-analysis was performed. Eligible studies were retrieved via both computerized searches and review of references. The summary relative risks (RRs) with 95% confidence interval (CI) for the highest vs. the lowest consumption of cruciferous vegetables were calculated. Heterogeneity and publication bias were also evaluated. Stratified analyses were performed as well. Three cohort and 7 case-control studies were included. A significantly decreased risk with renal cell carcinoma was observed in overall cruciferous vegetables consumption group (RR = 0.73; 95% CI, 0.63-0.83) and subgroup of case-control studies (RR = 0.69; 95% CI, 0.60-0.78), but not in cohort studies (RR = 0.96; 95% CI, 0.71-1.21). No heterogeneity and publication bias were detected across studies. Our findings supported that cruciferous vegetables consumption was related to the decreased risk of renal cell carcinoma. Because of the limited number of studies, further well-designed prospective studies and researches need to be conducted to better clarify the protective effect of cruciferous vegetables on renal cell carcinoma and potential mechanism.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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