Funded in part by International Nut and Dried Fruit Council
Frequency of nut consumption and mortality risk in the PREDIMED nutrition intervention trial
Guasch-Ferré M, Bulló M, Martínez-González MÁ, Ros E, Corella D, Estruch R, Fitó M, Arós F, Wärnberg J, Fiol M, Lapetra J, Vinyoles E, Lamuela-Raventós RM, Serra-Majem L, Pintó X, Ruiz-Gutiérrez V, Basora J, Salas-Salvadó J, PREDIMED study group
BMC medicine · 107 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Not stated
Who paid for it
- Funding
- Industry funded
- University or hospital
- Universidad de Málaga
- University or hospital
- Universitat de València
- University or hospital
- Universidad de Navarra
- University or hospital
- Universidad de Las Palmas de Gran Canaria
- Industry group
- International Nut and Dried Fruit Council
- Government
- Instituto de Salud Carlos III
- Government
- European Regional Development Fund
- Authors
- At least one author declares a financial tie to industry
Based on 7 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2013-07-16 · BMC Med · vol. 11 · issue 1 · p. 164
- Publisher
- BioMed Central
- Cited
- 158 citations · more than 99% of similar papers · 13.3× the field average
- Impact
- Top 10% most cited in its field
- References
- 41 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Nuts composition and effects · Antioxidant Activity and Oxidative Stress · Nutritional Studies and Diet
- Keywords
- Medicine, Mediterranean diet, National Death Index, Hazard ratio, Nut, Proportional hazards model, Demography, Lower risk, Confidence interval, Cohort study, Prospective cohort study, Risk of mortality, Environmental health, Internal medicine
- MeSH
- humans, nuts, coronary disease, plant oils, risk factors, cohort studies, longitudinal studies, follow-up studies, feeding behavior, diet, mediterranean, aged, aged, 80 and over, middle aged, spain, female, male, olive oil
18 authors
From ES
- Marta Liu Guasch-FerréInstitut de Recerca Biomèdica Catalunya Sud; Universitat Rovira i Virgili
- Mònica BullóInstituto de Salud Carlos III; Institut de Recerca Biomèdica Catalunya Sud; Centro de Investigación Biomédica en Red; Universitat Rovira i Virgili
- Miguel Ángel Martínez‐GonzálezUniversidad de Navarra
- Emilio Peña RosInstituto de Salud Carlos III; Centro de Investigación Biomédica en Red; Universitat de Barcelona
- Dolores CorellaUniversitat de València
- Ramón EstruchInstituto de Salud Carlos III; Centro de Investigación Biomédica en Red; Consorci Institut D'Investigacions Biomediques August Pi I Sunyer; Universitat de Barcelona
Abstract
Background
Prospective studies in non-Mediterranean populations have consistently related increasing nut consumption to lower coronary heart disease mortality. A small protective effect on all-cause and cancer mortality has also been suggested. To examine the association between frequency of nut consumption and mortality in individuals at high cardiovascular risk from Spain, a Mediterranean country with a relatively high average nut intake per person.
Methods
We evaluated 7,216 men and women aged 55 to 80 years randomized to 1 of 3 interventions (Mediterranean diets supplemented with nuts or olive oil and control diet) in the PREDIMED ('PREvención con DIeta MEDiterránea') study. Nut consumption was assessed at baseline and mortality was ascertained by medical records and linkage to the National Death Index. Multivariable-adjusted Cox regression and multivariable analyses with generalized estimating equation models were used to assess the association between yearly repeated measurements of nut consumption and mortality.
Results
During a median follow-up of 4.8 years, 323 total deaths, 81 cardiovascular deaths and 130 cancer deaths occurred. Nut consumption was associated with a significantly reduced risk of all-cause mortality (P for trend3 servings/week (32% of the cohort) had a 39% lower mortality risk (hazard ratio (HR) 0.61; 95% CI 0.45 to 0.83). A similar protective effect against cardiovascular and cancer mortality was observed. Participants allocated to the Mediterranean diet with nuts group who consumed nuts>3 servings/week at baseline had the lowest total mortality risk (HR 0.37; 95% CI 0.22 to 0.66).
Conclusions
Increased frequency of nut consumption was associated with a significantly reduced risk of mortality in a Mediterranean population at high cardiovascular risk.Please see related commentary: http://www.biomedcentral.com/1741-7015/11/165.
Trial registration
Clinicaltrials.gov. International Standard Randomized Controlled Trial Number (ISRCTN): 35739639. Registration date: 5 October 2005.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.