Combined fish oil and high oleic sunflower oil supplements neutralize their individual effects on the lipid profile of healthy men
Hlais S, El-Bistami D, El Rahi B, Mattar MA, Obeid OA
Lipids · 23 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2013-07-25 · Lipids · vol. 48 · issue 9 · pp. 853–861
- Publisher
- Wiley
- Cited
- 38 citations · more than 78% of similar papers · 1.3× the field average
- References
- 36 works
- Access
- Paywalled
- Research areas
- Fatty Acid Research and Health · Diet, Metabolism, and Disease · Dietary Effects on Health
- Keywords
- Lipidology, Clinical chemistry, Sunflower oil, Fish oil, Fish <Actinopterygii>, Food science, Chemistry, Biology, Biochemistry, Fishery
- MeSH
- animals, humans, cholesterol, insulin, blood glucose, lipids, fatty acids, omega-3, triglycerides, fish oils, plant oils, body mass index, drug administration schedule, analysis of variance, single-blind method, blood pressure, time factors, dietary supplements, adolescent, adult, male, cholesterol, ldl, young adult, sunflower oil, glycated hemoglobin
5 authors
From LB
- Sani HlaisAmerican University of Beirut
- Dunia El‐BistamiAmerican University of Beirut
- Berna RahiAmerican University of Beirut
- Mohab MattarAmerican University of Beirut
- Omar Obeid · correspondingAmerican University of Beirut
Abstract
Both n-3 and n-9 fatty acids share a common metabolic pathway and can potentially and individually improve cardiovascular disease risk factors. Dietary n-6 is known to weaken the efficacy of n-3 fatty acids due to competition for the same enzymes. Still unclear is whether a similar competition exists between n-3 and n-9 fatty acids. Thus, a 12-week intervention study was conducted to investigate the effect of different combinations of fish oil and high-oleic sunflower oil (OSO) on healthy subjects. Included were five groups (98 subjects): three groups received a fixed amount of n-9 (8 g/day) with varying amounts of n-3 (1, 2 or 4 g/day), one group was given n-3 fatty acids only (2 g/day) and another was given n-9 only (8 g/day). We found that fish oil supplement (2 g/day) was able to decrease TAG by about 13 %, this effect was diminished with the co-ingestion of n-9 (OSO). Intake of OSO (8 g/day) reduced both total and LDL cholesterol by about 10 %, this effect was reduced by the addition of fish oil. Both fish oil and OSO failed to have any significant effect on both glycemic and blood pressure parameters. In conclusion; the impact of oleic acid (n-9) on total and LDL cholesterol was altered by the addition fish oil (n-3). These effects may have been the result of enzymatic competition between the two types of fatty acids.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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