Effects of wheat and oat-based whole grain foods on serum lipoprotein size and distribution in overweight middle aged people: a randomised controlled trial
Tighe P, Duthie G, Brittenden J, Vaughan N, Mutch W, Simpson WG, Duthie S, Horgan GW, Thies F
PloS one · 12 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
Based on full-text disclosure statement.
Publication
- Published
- 2013-08-05 · PLoS One · vol. 8 · issue 8 · p. e70436
- Publisher
- Public Library of Science
- Cited
- 16 citations · more than 71% of similar papers · 0.7× the field average
- References
- 49 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Food composition and properties · Nutritional Studies and Diet · Seed and Plant Biochemistry
- Keywords
- Medicine, Overweight, Lipoprotein, Lipoprotein(a), Avena, Refined grains, Obesity, Whole grains, Blood lipids, Internal medicine, Physiology, Animal science, Food science, Cholesterol, Biology, Agronomy
- MeSH
- humans, triticum, lipoproteins, adult, aged, middle aged, female, male, overweight, avena
9 authors
From GB
- Paula TigheUniversity of Aberdeen
- Garry G. DuthieUniversity of Aberdeen
- Julie BrittendenUniversity of Aberdeen
- Nicholas J. VaughanUniversity of Aberdeen
- William James MutchNational Health Service; NHS Grampian
- William G. SimpsonNational Health Service; NHS Grampian
Abstract
Introduction
Epidemiological studies suggest three daily servings of whole-grain foods (WGF) might lower cardiovascular disease risk, at least partly by lowering serum lipid levels. We have assessed the effects of consuming three daily portions of wholegrain food (provided as wheat or a mixture of wheat and oats) on lipoprotein subclass size and concentration in a dietary randomised controlled trial involving middle aged healthy individuals.
Methods
After a 4-week run-in period on a refined diet, volunteers were randomly allocated to a control (refined diet), wheat, or wheat + oats group for 12 weeks. Our servings were determined in order to significantly increase the intakes of non starch polysaccharides to the UK Dietary Reference Value of 18 g per day in the whole grain groups (18.5 g and 16.8 g per day in the wheat and wheat + oats groups respectively in comparison with 11.3 g per day in the control group). Outcome measures were serum lipoprotein subclasses' size and concentration. Habitual dietary intake was assessed prior and during the intervention. Of the 233 volunteers recruited, 24 withdrew and 3 were excluded.
Results
At baseline, significant associations were found between lipoprotein size and subclasses' concentrations and some markers of cardiovascular risk such as insulin resistance, blood pressure and serum Inter cellular adhesion molecule 1 concentration. Furthermore, alcohol and vitamin C intake were positively associated with an anti-atherogenic lipoprotein profile, with regards to lipoprotein size and subclasses' distribution. However, none of the interventions with whole grain affected lipoprotein size and profile.
Conclusion
Our results indicate that three portions of wholegrain foods, irrelevant of the type (wheat or oat-based) do not reduce cardiovascular risk by beneficially altering the size and distribution of lipoprotein subclasses.
Trial registration
www.Controlled-Trials.com ISRCTN 27657880.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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