Central aortic blood pressure of hypertensive men during short-term cold exposure
Hintsala H, Kandelberg A, Herzig KH, Rintamäki H, Mäntysaari M, Rantala A, Antikainen R, Keinänen-Kiukaanniemi S, Jaakkola JJ, Ikäheimo TM
American journal of hypertension · 47 citations
How it was studied
- Design
- Case-control study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- Terveyden ja hyvinvoinnin laitos
- Government
- National Institutes of Health
Based on 2 listed funder(s).
Publication
- Published
- 2013-08-20 · Am J Hypertens · vol. 27 · issue 5 · pp. 656–664
- Publisher
- Oxford University Press
- Cited
- 62 citations · more than 92% of similar papers · 4.0× the field average
- Impact
- Top 10% most cited in its field
- References
- 36 works
- Access
- Paywalled
- Research areas
- Climate Change and Health Impacts · Cardiovascular Health and Disease Prevention · Sodium Intake and Health
- Keywords
- Medicine, Blood pressure, Cardiology, Internal medicine, Population, Aortic pressure, Pulse pressure
- MeSH
- aorta, brachial artery, humans, hypertension, hypothermia, risk factors, case-control studies, manometry, seasons, sex factors, body temperature regulation, time factors, aged, middle aged, finland, male, cold temperature, arterial pressure
10 authors
From FI
- Heidi E. HintsalaUniversity of Oulu
- A. KandelbergUniversity of Oulu
- Karl‐Heinz HerzigKuopio University Hospital; University of Oulu
- Hannu RintamäkiFinnish Institute of Occupational Health; University of Oulu
- Matti MäntysaariUniversity of Oulu
- Aino K. RantalaUniversity of Oulu
Abstract
Background
Short- and long-term exposures to cold increase blood pressure and may explain the higher wintertime cardiovascular morbidity and mortality. Hypertensive subjects may be more susceptible to adverse cold-related cardiovascular health effects. The aim of our study was to assess the effect of short-term cold exposure on central aortic blood pressure among untreated hypertensive men.
Methods
We conducted a population-based recruitment of 41 hypertensive men and a control group of 20 men without hypertension (aged 55-65 years) who underwent whole-body cold exposure (15-minute exposure to temperature -10 °C, wind 3 m/s, winter clothes). Central aortic blood pressure, augmentation index, and subendocardial viability ratio were measured by radial artery applanation tonometry.
Results
Short-term cold exposure increased the central aortic blood pressure similarly both in both hypertensive men, from 130/93 to 162/107 mm Hg (P < 0.001) and men in the control group, from 114/81 to 142/91 mmHg (P < 0.001). Augmentation index increased by 12% (from 10% to 22%, P < 0.001; and from 16% to 28%, P < 0.001, respectively), whereas subendocardial viability ratio decreased 10% (from 188% to 177%, P = 0.001; and from 203% to 193%, P = 0.01, respectively) during cold exposure in both hypertensive men and control subjects.
Conclusions
Short-term cold exposure increases central aortic blood pressure and cardiac workload, and myocardial oxygen demand slightly increases in relation to blood supply in untreated hypertensive middle-aged men. Because of the higher baseline blood pressure among hypertensive subjects, the cold-induced rise in central aortic blood pressure may increase the risk of adverse cardiovascular health effects.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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